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Flavonol Glycosides From Euphorbia Microsciadia Bioss. With Their Immunomodulatory Activities



Ghanadian SM1 ; Ayatollahi AM2 ; Afsharypour S3 ; Hareem S4 ; Abdalla OM4 ; Bankeu JJK5
Authors
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Authors Affiliations
  1. 1. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Pharmacy andPhytochemistry Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Health. eFaculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dr. Panjwani Center for Molecular Medicine and Drug Research, Sciences, University of Karachi, Karachi-75270, Pakistan
  5. 5. Department of Organic Chemistry, Faculty of Science, TWAS Research Unit of University of Yaounde I, Yaounde, Cameroon

Source: Iranian Journal of Pharmaceutical Research Published:2012

Abstract

Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques. The immunomodulatory activities of isolated compounds were compared using standard T-cell proliferation assay. These data showed that lymphocyte suppression activity of flavonoids (1-4) were comparatively lower than prednisolon as a standard drug. Immunosuppressive activity of flavonoids with hydroxyl groups at both 3′-and 4′-positions in their B-ring (Q3Gal) were more than those with 3′-,4′-and 5′-hydroxyl substitution (M3Gal). In these compounds, Q3Gal showed the most inhibitory activity, whereas M3Gal showed the least lymphocyte antiprolifeartive activity. © 2012 by School of Pharmacy.
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