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The Effect of Intravenous Tranexamic Acid on Preventing the Progress of Cerebral Hemorrhage in Patients With Brain Traumatic Injuries Compared to Placebo: A Randomized Clinical Trial Publisher



Mojallal F1 ; Nikooieh M2 ; Hajimaghsoudi M1 ; Baqherabadi M2 ; Jafari M2 ; Esmaeili A2 ; Karimi NM2 ; Zarepur E3
Authors
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Authors Affiliations
  1. 1. Trauma Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2020


Abstract

Background: Head trauma is one of the common reasons for patient attendance in the emergency ward. This study investigated the effect of tranexamic acid as a cheap, easily available antifibrinolytic drug on reducing the progress of cerebral hemorrhage compared to placebo. Methods: This double-blind controlled clinical trial was performed on 120 traumatized patients presenting to the emergency room of Shahid Rahnemoon hospital during 2014-2015, Yazd, Iran. Those patients who met the inclusion criteria were randomly allocated into 2 groups. Group A received tranexamic acid, while group B received placebo parenterally. Finally, 56 patients in Group A and 44 in Group B were analyzed. The patients underwent brain CT scan and were followed up for ICU stay in days. Also, the number of patients who died during the first 7 days of hospitalization was recorded. The data were analyzed with SPSS20 using independent samples t test and chi-square test. Results: The mean age of the patients was 41±20.27 years. Also, 20 patients (20%) were female and 80 were male (80%). There was no significant difference between the drug group and placebo group in the rate of hemorrhage volume progress (p=0.824). Regarding patients’ ICU stay, the ICU stay of the tranexamic acid group decreased significantly compared to the placebo group (p=0.001). No significant difference was found between the intervention group and placebo group in the mortality rate of patients during the first 7 days of hospitalization (p=0.236). Conclusion: Tranexamic acid has no effect on reducing cerebral hemorrhage volume in patients. Although this drug was not effective in reducing mortality rate in patients, it decreased their ICU stay. © Iran University of Medical Sciences
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