Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Serum Uric Acid Level With the Severity of Brain Injury and Patient’S Outcome in Severe Traumatic Brain Injury Publisher



Hatefi M1 ; Dastjerdi MM2 ; Ghiasi B3 ; Rahmani A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurosurgery, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran
  2. 2. Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Nephrology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran
  4. 4. Student’s Researches Committee, Ilam University of Medical Sciences, Ilam, Iran

Source: Journal of Clinical and Diagnostic Research Published:2016


Abstract

Introduction: The prognostic value of serum Uric Acid (UA) levels in Traumatic Brain Injury (TBI) is unclear. Aim: To investigate the relationship between serum UA levels and prognosis of patients with TBI when in hospital and at six months after discharge. Materials and Methods: All patients attended our emergency department during July 2014 and December 2015 and were consecutively entered into the study and among 890 evaluated candidates based on inclusion criteria we finally investigated the serum UA levels of 725 TBI patients. Computed Tomography (CT) images of the brain were obtained within the first 24 hours of hospitalization. Outcome was assessed using the Glasgow Outcome Scale (GOS) score at discharge and at six months after discharge. Results: Data of 725 patients (42.89% men; mean age: 54.69 ± 12.37 years) were analyzed. Mean ± Standard Deviation (SD) of GCS scores was 4.65 ± 1.76. Serum levels of UA, when in hospital and at six months after discharge, among those who died were lower than those who survived (in hospital: 0.126 ± 0.026 vs. 0.243 ± 0.942 mmol/l, p = 0.000; 6 months post-discharge: 0.130 ± 0.044 vs. 0.286 ± 0.069 mmol/l, p<0.001). The mean UA plasma was significantly different between deceased and alive patients according to GOS scores (p<0.001 and p=0.030, respectively). The UA levels showed a significant relationship with GCS scores and severity of brain injury assessed using the Marshall Classification Score (p=0.005). Conclusion: Our results showed a strong relationship between UA levels and patients' outcomes either in hospital or at six months after discharge. Serum UA level could be considered as a valuable marker for evaluating the severity of brain injury and outcomes of TBI. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.
Related Docs
View other Related Docs
1. Correlation Between Serum Homocysteine Levels and Outcome of Patients With Severe Traumatic Brain Injury, World Neurosurgery (2016)
2. Prognostic Factors in Traumatic Brain Injuries in Emergency Department, Journal of Research in Medical Sciences (2022)
3. The Effect of Intravenous Tranexamic Acid on Preventing the Progress of Cerebral Hemorrhage in Patients With Brain Traumatic Injuries Compared to Placebo: A Randomized Clinical Trial, Medical Journal of the Islamic Republic of Iran (2020)
4. Predictors of Traumatic Brain Injury Mortality: In Adults (18-45 Years) Trauma Patients, Trauma Monthly (2024)
5. Association Between Outcome of Severe Traumatic Brain Injury and Demographic, Clinical, Injury-Related Variables of Patients, Iranian Journal of Nursing and Midwifery Research (2018)
6. Spironolactone in Preventing Hypokalemia Following Traumatic Brain Injury, Chinese Journal of Traumatology - English Edition (2010)
7. Cerebral Vasospasm Following Traumatic Subarachnoid Hemorrhage, Journal of Research in Medical Sciences (2009)
8. The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity, Parkinson's Disease (2015)
Experts (# of related papers)
View all Related Experts
Parviz Kashefi (4)
Mehdi Mahmoodkhani (4)
Other Related Docs
9. The Impact of Body Mass Index Changes on Traumatic Brain Injury Patients’ Outcomes During Hospitalization, Chinese Journal of Traumatology - English Edition (2024)
10. Association Between Major Dietary Patterns and Parkinson’S Disease Risk: A Case–Control Study, Neurological Sciences (2024)
11. Predictive Power of the Etbi Score for 30 Day Outcome in Elderly Patients With Traumatic Brain Injury, Scientific Reports (2024)
12. The Effect of Tranexamic Acid on Traumatic Brain Hematomas, Journal of Isfahan Medical School (2016)
13. Serum Uric Acid Level in Patients With Relapsing-Remitting Multiple Sclerosis, Journal of Clinical Neuroscience (2013)
14. Prevalence of Acute Kidney Injury in Patients With Sepsis in Isfahan, Iran, Translational Research in Urology (2021)
15. The Effect of Low Dietary Inflammatory Index Score Formula on Inflammatory, Metabolic, and Clinical Outcomes in Critically Ill Traumatic Brain Injury Patients: A Single-Blind Randomized Controlled Pilot Study, Food Science and Nutrition (2023)
16. The Association Between Hyperuricemia and the Risk of Acute Kidney Injury; a Systematic Review and Meta-Analysis, Journal of Nephropharmacology (2023)
17. Predisposing Factors for Serum Sodium Disturbance in Patients With Severe Traumatic Brain Injury (Sbi), Turkish Journal of Medical Sciences (2010)
18. Comparison of the Accuracy of Two Methods on Detection of the Prognosis of Mortality in Patients With Trauma Admitted to the Intensive Care Units of Alzahra Hospital, Isfahan, Iran, in 2015, Journal of Isfahan Medical School (2018)
19. Physiologic Scoring Systems Versus Glasgow Coma Scale in Predicting In-Hospital Mortality of Trauma Patients; a Diagnostic Accuracy Study, Archives of Academic Emergency Medicine (2021)
20. The Effects of Gabapentin on Improvement of Consciousness Level in Patients With Traumatic Brain Injury: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2012)
21. Clinical Predictors of Abnormal Brain Computed Tomography Findings in Mild Traumatic Brain Injury: A Cross-Sectional Study, Medicine (United States) (2023)
22. The Effect of Intravenous Tranexamic Acid Before and During Spinal Surgery in Bleeding Volume During and After Surgical Operation, Iranian Journal of Neurosurgery (2019)
23. Comparison of Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation Iii Scoring Systems on Detection Prognosis of Mortality in Patients With Trauma Admitted to the Intensive Care Unit, Journal of Isfahan Medical School (2019)
24. Utilizing Injury Severity Score, Glasgow Coma Scale, and Revised Trauma Score for Trauma-Related In-Hospital Mortality and Icu Admission Prediction; Originated From 7-Year Results of a Nationwide Multicenter Registry, Frontiers in Emergency Medicine (2024)
25. National Guidelines for Cognitive Assessment and Rehabilitation of Iranian Traumatic Brain Injury Patients, Archives of Iranian Medicine (2020)
26. The Prevalence of Acid-Base Disorders in Patients With Acute Poisoning in the Intensive Care Unit of Clinical Toxicology Department, Isfahan, Iran, Journal of Isfahan Medical School (2019)
27. The Effect of Pre-, Intra- and Postoperative Blood Glucose on Outcomes of Patients With Traumatic Brain Injury, Journal of Isfahan Medical School (2016)
28. Evaluation of the Various Methods of Fluid Resuscitation in Concussion and Its Relationship With Patient Outcomes, Journal of Isfahan Medical School (2016)
29. Targeting Mitochondrial and Brain Injury Markers in Acquired Brain Injuries: A Randomized, Double-Blind, Placebo-Controlled Study With Melatonin, Advanced Pharmaceutical Bulletin (2022)
30. Comparison of Simplified Acute Physiology Score-Iii and Mortality Probability Model-Iii in Trauma Patients, Journal of Isfahan Medical School (2019)
31. Effect of Methylphenidate on Icu and Hospital Length of Stay in Patients With Severe and Moderate Traumatic Brain Injury, Clinical Neurology and Neurosurgery (2006)
32. Correlation of Homocysteine With Cerebral Hemodynamic Abnormality, Endothelial Dysfunction Markers, and Cognition Impairment in Patients With Traumatic Brain Injury, World Neurosurgery (2017)
33. Predictive Validity and Inter-Rater Reliability of the Persian Version of Full Outline of Unresponsiveness Among Unconscious Patients With Traumatic Brain Injury in an Intensive Care Unit, Neurocritical Care (2017)
34. Comparison of Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation Ii Scoring Systems on Detection Prognosis of Mortality in Patients With Trauma Admitted to the Intensive Care Unit, Journal of Isfahan Medical School (2018)
35. Gastrointestinal Bleeding Following Traumatic Brain Injury: A Clinical Study on Predisposing Factors and Outcomes, Caspian Journal of Internal Medicine (2024)