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Hantzsch-Type Dihydropyridines and Biginelli-Type Tetrahydropyrimidines: A Review of Their Chemotherapeutic Activities Publisher Pubmed



Sepehri S1 ; Sanchez HP2 ; Fassihi A1, 2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Bioinformatics and High Performance Computing Research Group, Computer Science Department, Universidad Catolica San Antonio de Murcia (UCAM), Spain

Source: Journal of Pharmacy and Pharmaceutical Sciences Published:2015


Abstract

Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4- tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis and the diverse pharmacologic properties that these scaffolds present. 1,4-Dihydropyridines and 1,2,3,4-tetrahydropyrimidines are usually regarded as analogous in several aspects. They are both prepared in multi-component reactions using very similar starting materials and synthesis protocols. This leads to common structural features between 1,4-DHPs and 1,2,3,4- THPMs, as well several related biological effects. For example, they share many pharmacological features such as analgesic, anti-tumor, antioxidant, anti-inflammatory, antitubercular, antibacterial, cardiovascular and adrenoceptor blocking activities. Numerous reviews have been devoted to the chemistry and cardiovascular effects of these compounds. However, the lack of a comprehensive literature overview on the chemotherapeutic ability of these scaffolds is behind the present attempt to provide a detailed survey of 1,4-DHPs and 1,2,3,4- THPMs and their structural features as chemotherapeutic agents. © 2015, J Pharm Pharm Sci. All right reserved.
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