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Antimicrobial Evaluation of Some Novel Derivatives of 3,4- Dihydropyrimidine-2(1H)-One



Jalali M1 ; Mahdavi M2 ; Memarian HR3 ; Ranjbar M3 ; Soleymani M3 ; Fassihi A4 ; Abedi D2
Authors
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Authors Affiliations
  1. 1. Food Security Research Center and School of Food Science Nutrition and, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Chemistry, Faculty of Sciences, University of Isfahan, Isfahan, Iran
  4. 4. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Research in Pharmaceutical Sciences Published:2012

Abstract

The antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. Significant antimicrobial activity (MIC=32, 64 μg/ml) was observed. Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria and Staphylococcus aureus as Gram-positive bacteria were determined to be the most susceptible pathogens in this study. The highest inhibitory activity was observed against Gram-negative microorganisms. The widest spectrum of antibacterial activity was exerted by C6 and C22. Most of the compounds had remarkable antifungal activity (MIC=32 μg/ml).
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