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Antimicrobial Evaluation of Some Novel Derivatives of 3,4- Dihydropyrimidine-2(1H)-One



Jalali M1 ; Mahdavi M2 ; Memarian HR3 ; Ranjbar M3 ; Soleymani M3 ; Fassihi A4 ; Abedi D2
Authors

Source: Research in Pharmaceutical Sciences Published:2012

Abstract

The antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. Significant antimicrobial activity (MIC=32, 64 μg/ml) was observed. Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria and Staphylococcus aureus as Gram-positive bacteria were determined to be the most susceptible pathogens in this study. The highest inhibitory activity was observed against Gram-negative microorganisms. The widest spectrum of antibacterial activity was exerted by C6 and C22. Most of the compounds had remarkable antifungal activity (MIC=32 μg/ml).
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