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Synthesis and Antimicrobial Activity of Novel Derivatives of Biginelli Pyrimidines Publisher



Sedaghati B1 ; Fassihi A1 ; Arbabi S1 ; Ranjbar M2 ; Memarian HR2 ; Saghaie L1 ; Omidi A1 ; Sardari A1 ; Jalali M3 ; Abedi D4
Authors

Source: Medicinal Chemistry Research Published:2012


Abstract

A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 lg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 lg/ml, 3d, 7b, and 8b with MIC = 64 lg/ml against C. albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 lg/ml. © Springer Science+Business Media, LLC 2011
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