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Synthesis and Antimicrobial Activity of Novel Derivatives of Biginelli Pyrimidines Publisher



Sedaghati B1 ; Fassihi A1 ; Arbabi S1 ; Ranjbar M2 ; Memarian HR2 ; Saghaie L1 ; Omidi A1 ; Sardari A1 ; Jalali M3 ; Abedi D4
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Chemistry, Faculty of Sciences, University of Isfahan, Isfahan, 81746-73441, Iran
  3. 3. School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Medicinal Chemistry Research Published:2012


Abstract

A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 lg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 lg/ml, 3d, 7b, and 8b with MIC = 64 lg/ml against C. albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 lg/ml. © Springer Science+Business Media, LLC 2011
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