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Tissue Engineering: Dentin – Pulp Complex Regeneration Approaches (A Review) Publisher Pubmed



Hashemibeni B1 ; Khoroushi M2 ; Foroughi MR3 ; Karbasi S4 ; Khademi AA5
Authors
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Authors Affiliations
  1. 1. Torabinejad Dentistry Research Center and Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Dental Materials Research Center and Department of Operative and Art, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Dental Materials Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Torabinejad Dentistry Research Center and Department of Endodonics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Tissue and Cell Published:2017


Abstract

Dental pulp is a highly specialized tissue that preserves teeth. It is important to maintain the capabilities of dental pulp before a pulpectomy by creating a local restoration of the dentin-pulp complex from residual dental pulp. The articles identified were selected by two reviewers based on entry and exit criteria. All relevant articles indexed in PubMed, Springer, Science Direct, and Scopus with no limitations from 1961 to 2016 were searched. Factors investigated in the selected articles included the following key words: Dentin-Pulp Complex, Regeneration, Tissue Engineering, Scaffold, Stem Cell, and Growth Factors. Of the 233 abstracts retrieved, the papers which were selected had evaluated the clinical aspects of the application of dentin-pulp regeneration. Generally, this study has introduced a new approach to provoke the regeneration of the dentin-pulp complex after a pulpectomy, so that exogenous growth factors and the scaffold are able to induce cells and blood vessels from the residual dental pulp in the tooth root canal. This study further presents a new strategy for local regeneration therapy of the dentin-pulp complex. This review summarizes the current knowledge of the potential beneficial effects derived from the interaction of dental materials with the dentin-pulp complex as well as potential future developments in this exciting field. © 2017 Elsevier Ltd
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