Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Gender Differences in Response to Vitamin E and C in Gentamicin Induced Nephrotoxicity in Wistar Rats Publisher



Safari T1 ; Nematbakhsh M2 ; Miri S1 ; Ghofran O1 ; Fereidooni F1 ; Niazi AA3 ; Bagheri H4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran
  4. 4. Department of Medical English, Zahedan University of Medical Sciences, Iran

Source: Journal of Nephropathology Published:2017


Abstract

Background: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives: This study aims to investigate the possibility of any gender difference in response to antioxidant effects vitamins E and C in gentamicin-induced nephrotoxicity. Materials and Methods: Wistar rats were randomly assigned to 6 groups each including both male and female rats. The first and second groups received saline (control group) and almond oil, the third group received gentamicin. The fourth group received a regular dose of gentamicin + vitamin E. Similarly, the fifth group received a regular dose of gentamicin + vitamin C. The sixth group received a dose of gentamicin + vitamin C and E simultaneously constantly. This protocol continued for 9 days. Results: Gentamicin increased significantly urea, creatinine (Cr) and malondialdehyde (MDA), but it decreased superoxidase dismutase (SOD) level (P < 0.05). Treatment with antioxidant vitamins improved urea, creatinine, MDA, and SOD serum level significantly in both genders (P <0.05). Likewise, kidney MDA level enhanced significantly (P <0.05) and treatment with antioxidant vitamins reduced MDA level too (P <0.05). Gentamicin decreased kidney SOD activity in male and female rats (P <0.05). However, treatment with antioxidant vitamins did not improve its level in male rats, while in female rats, vitamins E and C compensated for kidney SOD activity. Conclusions: Antioxidant vitamins modified gentamicin-induced nephrotoxicity in both genders, with some difference in response to vitamins E and C between the genders, that was higher in female rats. © 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention.
Related Docs
View other Related Docs
1. Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats, Scientifica (2016)
2. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant Against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model, International Journal of Nephrology (2012)
3. Sex Difference in Gentamicin-Induced Nephrotoxicity: Influence of L-Arginine in Rat Model, International Journal of Preventive Medicine (2018)
4. Nitric Oxide Metabolite Changes in Gentamicin-Induced Nephrotoxicity; the Effects of Antioxidant Vitamins, Journal of Renal Injury Prevention (2018)
5. Preventive and Curative Effect of Garlic on Nephrotoxic Effect of Gentamicin in Rat, Journal of Babol University of Medical Sciences (2014)
6. Lack of Nephroprotective Efficacy of Althaea Officinalis Flower Extract Against Gentamicin Renal Toxicity in Male Rats, International Journal of Preventive Medicine (2014)
7. Preventive and Curative Activity of Garlic Extract on Gentamicin-Induced Oxidative Stress, Journal of Isfahan Medical School (2014)
8. Vitamin E in the Prevention of Vancomycin-Induced Nephrotoxicity, Research in Pharmaceutical Sciences (2020)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (49)
Ardeshir Talebi (37)
Other Related Docs
9. Ameliorative Impact of Ezetimibe on Gentamicin-Induced Kidney Damage; a Histopathological Perspective Study, Journal of Nephropathology (2022)
10. The Preventive Effect of Berberis Vulgaris Extract on Contrast-Induced Acute Kidney Injury, Journal of Nephropathology (2017)
11. Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences, Asian Pacific Journal of Cancer Prevention (2017)
12. Administration of Vitamin E and Losartan As Prophylaxes in Cisplatin-Induced Nephrotoxicity Model in Rats, Journal of Nephrology (2012)
13. Vancomycin-Induced Nephrotoxicity in Rats: Is Enzyme Elevation a Consistent Finding in Tubular Injury?, Journal of Nephrology (2007)
14. Some Evidence for Sex-Based Differences in Cisplatininduced Nephrotoxicity in Rats, Clinical and Experimental Medical Letters (2012)
15. The Protective Role of Endogenous Nitric Oxide Donor (L-Arginine) in Cisplatin-Induced Nephrotoxicity: Gender Related Differences in Rat Model, Journal of Research in Medical Sciences (2011)
16. The Role of Angiotensin Ii Receptor 1 (At1) Blockade in Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Differences, Renal Failure (2012)
17. Preventive Role of Endothelin Antagonist on Kidney Ischemia: Reperfusion Injury in Male and Female Rats, International Journal of Preventive Medicine (2015)
18. Ethanolic Extract of Garlic for Attenuation of Gentamicin-Induced Nephrotoxicity in Wistar Rats, Iranian Journal of Kidney Diseases (2013)
19. Paradoxical Effects of Atorvastatin on Renal Tubular Cells an Experimental Investigation, Iranian Journal of Kidney Diseases (2015)
20. Preventive and Curative Effects of Ginger Extract Against Histopathologic Changes of Gentamicin-Induced Tubular Toxicity in Rats, International Journal of Preventive Medicine (2013)
21. Protection of Renal Tubular Cells by Antioxidants: Current Knowledge and New Trends, Cell Journal (2015)
22. Antioxidant Activity and Preventive Effect of Aqueous Leaf Extract of Aloe Vera on Gentamicin-Induced Nephrotoxicity in Male Wistar Rats, Clinica Terapeutica (2014)
23. Pretreatment Effect of D-Limonene on Oxidative Stress Induced by Renal Ischemia-Reperfusion Injury in Rats, Journal of Babol University of Medical Sciences (2022)
24. N-Acetylcysteine and Cisplatin-Induced Nephrotoxicity: Is It a Suitable Antioxidant Supplementation to Prevent Nephrotoxicity in Male or Female Rats?, Journal of Isfahan Medical School (2013)
25. Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female, Nephro-Urology Monthly (2013)
26. Pomegranate Flower Extract Does Not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats, International Journal of Preventive Medicine (2014)
27. Has Vitamin E Any Shreds of Evidence in Cisplatin-Induced Toxicity, Journal of Biochemical and Molecular Toxicology (2019)
28. Evidence Against Protective Role of Sex Hormone Estrogen in Cisplatin-Induced Nephrotoxicity in Ovarectomized Rat Model, Toxicology International (2013)
29. The Effect of Iron-Vitamin C Co-Supplementation on Biomarkers of Oxidative Stress in Iron-Deficient Female Youth, Biological Trace Element Research (2013)
30. Dextrose Hydration May Promote Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Difference, Indonesian Biomedical Journal (2019)
31. Testosterone and Zinc Supplementations on Renal Ischemia-Reperfusion Injury in Orchiectomized Rats, International Journal of Preventive Medicine (2019)
32. Carvacrol Exerts Nephroprotective Effect in Rat Model of Diclofenac-Induced Renal Injury Through Regulation of Oxidative Stress and Suppression of Inflammatory Response, Heliyon (2021)
33. N-Acetylcysteine Prevents Kidney and Lung Disturbances in Renal Ischemia/ Reperfusion Injury in Rat, International Journal of Preventive Medicine (2013)
34. Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients, International Journal for Vitamin and Nutrition Research (2009)
35. Protective Effects of the Morus Alba L. Leaf Extracts on Cisplatininduced Nephrotoxicity in Rat, Research in Pharmaceutical Sciences (2013)
36. The Protective Effect of Γ‑Aminobutyric Acid on Kidney Injury Induced by Renal Ischemia‑Reperfusion in Ovariectomized Estradiol‑Treated Rats, International Journal of Preventive Medicine (2016)
37. A Combination of Vitamin C and Losartan for Cisplatininduced Nephrotoxicity in Rats, Iranian Journal of Kidney Diseases (2012)
38. Evaluation of Serum Level of Carnitine in Children With Acute Pyelonephritis (Apn) Compared to Healthy Children, Reviews on Recent Clinical Trials (2021)
39. Effect of Aqueous Extract of Rheum Ribes on Cisplatin-Induced Nephrotoxicity in Rat, Journal of Pharmacy and Bioallied Sciences (2013)
40. Effect of Testosterone on Cisplatin-Induced Nephrotoxicity in Surgically Castrated Rats, Nephro-Urology Monthly (2014)
41. The Role of Vitamin C in Vanadyl-Sulfate-Induced Nephrotoxicity and Hepatotoxicity, Journal of Isfahan Medical School (2016)
42. Oxidative Stress and Hypertension: Possibility of Hypertension Therapy With Antioxidants, Journal of Research in Medical Sciences (2014)
43. Erythropoietin Ameliorates Genetamicin-Induced Renal Toxicity: A Biochemical and Histopathological Study, Journal of Nephropathology (2012)
44. A Comparative Study Pertaining to Deleterious Effects of Diclofenac Sodium and Meloxicam on Kidney Tissue in Rats, EXCLI Journal (2011)
45. The Protective Effect of Lycopene Supplement Against Vancomycin-Induced Nephrotoxicity; a Randomized Double-Blind Placebo-Controlled Clinical Trial, Journal of Renal Injury Prevention (2020)
46. A Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial of N -Acetylcysteine for Preventing Amphotericin B-Induced Nephrotoxicity, Expert Opinion on Drug Metabolism and Toxicology (2015)
47. The Evaluation of L-Arginine Prophylaxis and Treatment on Preventing Nephrotoxicity Cisplatin-Induced in Rat: Role of Gender Difference, Journal of Isfahan Medical School (2015)
48. Effect of Curcumin on Oxidative Stress, Inflammatory Response and Kidney Biochemical Parameters Among Kidney Disease Patients: A Systematic Review, Natural Products Journal (2023)
49. Hepatoprotective Effects of Iranian Hypericum Scabrum Essential Oils Against Oxidative Stress Induced by Acetaminophen in Rats, Brazilian Archives of Biology and Technology (2014)
50. Does Vitamin E Mitigate Cisplatin-Induced Nephrotoxicity in Cancer Patients: Results From a Randomized Placebo-Controlled Clinical Trial, Middle East Journal of Cancer (2020)