Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells

Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells Publisher Pubmed

Zavareh VA¹ ; Gharibi S^{1, 2} ; Hosseini Rizi M¹ ; Nekookar A¹ ; Mirhendi H^{1, 3} ; Rahimmalek M^{4, 5} ; Szumny A⁵

Show Affiliations

1. Core Research Facilities (CRF), Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
2. Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Wroclaw, 50-367, Poland
3. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
4. Department of Horticulture, College of Agriculture, Isfahan University of Technology, Isfahan, 84156-83111, Iran
5. Department of Food Chemistry and Biocatalysis, Wroclaw University of Environmental and Life Sciences, Wroclaw, 50-375, Poland

Source: Cells Published:2023

Abstract

Overcoming drug resistance and specifically targeting cancer stem cells (CSCs) are critical challenges in improving cancer therapy. Nowadays, the use of novel and native medicinal plants can provide new sources for further investigations for this purpose. The aim of this study was to assess the potential of S. bachtiarica, an endemic plant with diverse medicinal applications, in suppressing and targeting cancer and cancer stem cells in glioblastoma and breast cancer. The effect of S. bachtiarica on viability, migration, invasion, and clonogenic potential of MDAMB-231 and U87-MG cells was assessed in both two- and three-dimensional cell culture models. Additionally, we evaluated its effects on the self-renewal capacity of mammospheres. The experimental outcomes indicated that S. bachtiarica decreased the viability and growth rate of cells and spheroids by inducing apoptosis and inhibited colony formation, migration, and invasion of cells and spheroids. Additionally, colony and sphere-forming ability, as well as the expression of genes associated with EMT and stemness were reduced in mammospheres treated with S. bachtiarica. In conclusion, this study provided valuable insights into the anti-cancer effects of S. bachtiarica, particularly in relation to breast CSCs. Therefore, S. bachtiarica may be a potential adjuvant for the treatment of cancer. © 2023 by the authors.

Related Docs

1. Natural and Herbal Compounds Targeting Breast Cancer, a Review Based on Cancer Stem Cells, Iranian Journal of Basic Medical Sciences (2020)

2. Suppressive Role of Viola Odorata Extract on Malignant Characters of Mammosphere-Derived Breast Cancer Stem Cells, Clinical and Translational Oncology (2020)

3. Resveratrol As an Antitumor Agent for Glioblastoma Multiforme: Targeting Resistance and Promoting Apoptotic Cell Deaths, Acta Histochemica (2023)

4. A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells Via Gli-1 and Erk1/2 Pathway, Journal of Cellular Biochemistry (2017)

5. A2b Adenosine Receptor Agonist Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Stem Cells Via Erk1/2 Phosphorylation, Cellular Oncology (2018)

6. Cytotoxic Effect of Drimia Maritima Bulb Extract and Induction of Mitochondrial Apoptotic Signaling in Human Breast Cancer Cells, Mcf-7 and Mda-Mb-468, OncoTargets and Therapy (2018)

7. Anti-Tumor Effects of Ellagic Acid and Mesenchymal Stem Cell-Conditioned Medium on Breast Cancer Cells on the 3D Printed Pcl/Agarose Scaffolds, Journal of Drug Delivery Science and Technology (2024)

8. Competing Endogenous Rnas Regulatory Crosstalk Networks: The Messages From the Rna World to Signaling Pathways Directing Cancer Stem Cell Development, Heliyon (2024)

Experts (# of related papers)

View all Related Experts

Mahmoud Aghaei (3)

Mojtaba Panjehpour (2)

Style	Citing Format
MLA	Zavareh VA, et al.. "Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells." Cells, vol. 12, no. 23, 2023, pp. -.
APA	Zavareh VA, Gharibi S, Hosseini Rizi M, Nekookar A, Mirhendi H, Rahimmalek M, Szumny A (2023). Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells. Cells, 12(23), -.
Chicago	Zavareh VA, Gharibi S, Hosseini Rizi M, Nekookar A, Mirhendi H, Rahimmalek M, Szumny A. "Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells." Cells 12, no. 23 (2023): -.
Harvard	Zavareh VA et al. (2023) 'Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells', Cells, 12(23), pp. -.
Vancouver	Zavareh VA, Gharibi S, Hosseini Rizi M, Nekookar A, Mirhendi H, Rahimmalek M, et al.. Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells. Cells. 2023;12(23):-.
BibTex	@article{ author = {Zavareh VA and Gharibi S and Hosseini Rizi M and Nekookar A and Mirhendi H and Rahimmalek M and Szumny A}, title = {Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells}, journal = {Cells}, volume = {12}, number = {23}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Zavareh VA AU - Gharibi S AU - Hosseini Rizi M AU - Nekookar A AU - Mirhendi H AU - Rahimmalek M AU - Szumny A TI - Satureja Bachtiarica Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells JO - Cells VL - 12 IS - 23 SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract