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Resveratrol As an Antitumor Agent for Glioblastoma Multiforme: Targeting Resistance and Promoting Apoptotic Cell Deaths Publisher Pubmed



Karkonshayan S1 ; Aliashrafzadeh H2 ; Dianatmoghadam H3 ; Rastegarpouyani N4 ; Majidi M1 ; Zarei M2 ; Moradivastegani S5 ; Bahramvand Y6 ; Babaniamansour S7 ; Jafarzadeh E4
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  2. 2. Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of physiology, Faculty of medicine, physiology research center, Ahvaz jundishapur university of medical sciences, Ahvaz, Iran
  6. 6. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Pathology, School of Medicine, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran

Source: Acta Histochemica Published:2023


Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive brain and spinal cord tumors. Despite the significant development in application of antitumor drugs, no significant increases have been observed in the survival rates of patients with GBM, as GBM cells acquire resistance to conventional anticancer therapeutic agents. Multiple studies have revealed that PI3K/Akt, MAPK, Nanog, STAT 3, and Wnt signaling pathways are involved in GBM progression and invasion. Besides, biological processes such as anti-apoptosis, autophagy, angiogenesis, and stemness promote GBM malignancy. Resveratrol (RESV) is a non-flavonoid polyphenol with high antitumor activity, the potential of which, regulating signaling pathways involved in cancer malignancy, have been demonstrated by many studies. Herein, we present the potential of RESV in both single and combination therapy- targeting various signaling pathways- which induce apoptotic cell death, re-sensitize cancer cells to radiotherapy, and induce chemo-sensitizing effects to eventually inhibit GBM progression. © 2023 Elsevier GmbH
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