Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Use of Cellulose Nanocrystals for Potential Application in Topical Delivery of Hydroquinone Publisher Pubmed



Taheri A1, 2 ; Mohammadi M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery System Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184, Iran

Source: Chemical Biology and Drug Design Published:2015


Abstract

Nanotechnology-based drug delivery systems can enhance drug permeation through the skin and improve the drug stability. The biodegradability and biocompatibility of cellulose nanocrystals have made these nanoparticles good candidates to use in biomedical applications. The hyperpigmentation is a common skin disorder that could be caused by number of reasons such as sun exposure and pregnancy. Hydroquinone could inhibit the production of melanin and eliminate the discolorations of skin. This study is aimed at introducing cellulose nanocrystals as suitable carriers for drug delivery to skin. Prepared cellulose nanocrystals were characterized by dynamic light scattering and atomic force microscopy. The size of cellulose nanocrystals determined using dynamic light scattering was 301 ± 10 nm. Hydroquinone-cellulose nanocrystal complex was prepared by incubating of hydroquinone solution in cellulose nanocrystals suspension. The size of hydroquinone-cellulose nanocrystal complex determined using dynamic light scattering was 310 ± 10 nm. The hydroquinone content of the hydroquinone-cellulose complex was determined using UV/vis spectroscopy. Hydroquinone was bound to cellulose nanocrystals representing 79.3 ± 2% maximum binding efficiency when 1.1 mg hydroquinone was added to 1 mL of cellulose nanocrystals suspension (2 mg cellulose nanocrystal). The hydroquinone-cellulose nanocrystal complex showed an approximately sustained release profile of hydroquinone. Approximately, 80% of bound hydroquinone released in 4 h. The current study is aimed at introducing cellulose nanocrystals as suitable carriers for drug delivery to skin. The hydroquinone-cellulose nanocrystal complexes showed an approximately sustained release profile of hydroquinone. Approximately 80% of bound hydroquinone released in 4 h. © 2014 John Wiley & Sons A/S.
Related Docs
View other Related Docs
1. Preparation and Characterization of Metformin Surface Modified Cellulose Nanofiber Gel and Evaluation of Its Anti-Metastatic Potentials, Carbohydrate Polymers (2017)
2. Nanocrystalline Cellulose-Hyaluronic Acid Composite Enriched With Gm-Csf Loaded Chitosan Nanoparticles for Enhanced Wound Healing, Biomedical Materials (Bristol) (2019)
3. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
4. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
5. Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications, Advanced Healthcare Materials (2022)
6. Investigating the Performance of Drug Delivery System of Fluconazole Made of Nano–Micro Fibers Coated on Cotton/Polyester Fabric, Journal of Materials Science: Materials in Medicine (2017)
7. Carboxymethyl Cellulose-Based Wafer Enriched With Resveratrol-Loaded Nanoparticles for Enhanced Wound Healing, Drug Delivery and Translational Research (2020)
8. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (8)
Vajihe Akbari (4)
Other Related Docs
9. Dual Thermo- and Ph-Responsive Poly(N-Isopropylacrylamide-Co-(2-Dimethylamino) Ethyl Methacrylate)-G-Peg Nanoparticle System and Its Potential in Controlled Drug Release, Polymer Bulletin (2020)
10. Preparation, Optimization, and in Vitro–In Vivo Evaluation of Sorafenib-Loaded Polycaprolactone and Cellulose Acetate Nanofibers for the Treatment of Cutaneous Leishmaniasis, Drug Delivery and Translational Research (2023)
11. Polycaprolactone/Chitosan Blend Nanofibers Loaded by 5-Fluorouracil: An Approach to Anticancer Drug Delivery System, Polymers for Advanced Technologies (2018)
12. A Multifunctional Nanocomposite Spray Dressing of Kappa-Carrageenan-Polydopamine Modified Zno/L-Glutamic Acid for Diabetic Wounds, Materials Science and Engineering C (2020)
13. Montelukast Incorporated Poly(Methyl Vinyl Ether-Co-Maleic Acid)/Poly(Lactic-Co-Glycolic Acid) Electrospun Nanofibers for Wound Dressing, Fibers and Polymers (2017)
14. Injectable Gellan Gum/Lignocellulose Nanofibrils Hydrogels Enriched With Melatonin Loaded Forsterite Nanoparticles for Cartilage Tissue Engineering: Fabrication, Characterization and Cell Culture Studies, Materials Science and Engineering C (2020)
15. Fabrication and Characterization of a Novel Wound Dressing With Clindamycin Loaded Pva Nanoparticles for Acne Treatment, Fibers and Polymers (2022)
16. Preparation of an Injectable Doxorubicin Surface Modified Cellulose Nanofiber Gel and Evaluation of Its Anti-Tumor and Anti-Metastasis Activity in Melanoma, Biotechnology Progress (2018)
17. Preparation, Physicochemical, and Retinal Anti-Angiogenic Evaluation of Poloxamer Hydrogel Containing Dexamethasone/Avastin-Loaded Chitosan-N-Acetyl-L-Cysteine Nanoparticles, International Journal of Biological Macromolecules (2022)
18. Cellulosic Textile/Clove Nanocomposite As an Antimicrobial Wound Dressing: In Vitro and in Vivo Study, Colloids and Surfaces B: Biointerfaces (2022)
19. Fabrication, Characterization, and Drug Release Study of Vitamin C–Loaded Alginate/Polyethylene Oxide Nanofibers for the Treatment of a Skin Disorder, Polymers for Advanced Technologies (2019)
20. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
21. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)