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Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications Publisher Pubmed



Hajebi S1, 2 ; Yousefiasl S3 ; Rahimmanesh I4 ; Dahim A5 ; Ahmadi S6 ; Kadumudi FB7 ; Rahgozar N8 ; Amani S9 ; Kumar A10 ; Kamrani E11, 12 ; Rabiee M13 ; Borzacchiello A14 ; Wang X15 ; Rabiee N16, 17 Show All Authors
Authors
  1. Hajebi S1, 2
  2. Yousefiasl S3
  3. Rahimmanesh I4
  4. Dahim A5
  5. Ahmadi S6
  6. Kadumudi FB7
  7. Rahgozar N8
  8. Amani S9
  9. Kumar A10
  10. Kamrani E11, 12
  11. Rabiee M13
  12. Borzacchiello A14
  13. Wang X15
  14. Rabiee N16, 17
  15. Dolatshahipirouz A7
  16. Makvandi P18, 19, 20
Show Affiliations
Authors Affiliations
  1. 1. Department of Polymer Engineering, Sahand University of Technology, Tabriz, 51335-1996, Iran
  2. 2. Institute of Polymeric Materials, Sahand University of Technology, Tabriz, 51335-1996, Iran
  3. 3. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
  4. 4. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  5. 5. Department of Anesthesia, Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran
  6. 6. Department of Biology, Faculty of Sciences, University of Zabol, Sistan and Baluchestan, Zabol, 98613-35856, Iran
  7. 7. Department of Health Technology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark
  8. 8. Department of Chemistry, Amirkabir University of Technology, Tehran, 15875-4413, Iran
  9. 9. Department of Chemical Engineering, Sahand University of Technology, Tabriz, 51335-1996, Iran
  10. 10. Chitkara College of Pharmacy, Chitkara University, Himachal Pradesh, 174 103, India
  11. 11. Harvard-MIT Health Science and Technology, Cambridge, 02139, MA, United States
  12. 12. Wellman Center for Photomedicine, Harvard Medical School, Boston, 02139, MA, United States
  13. 13. Biomaterials Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 15875-4413, Iran
  14. 14. Institute for Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Naples, 80125, Italy
  15. 15. Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, 200032, China
  16. 16. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia
  17. 17. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Gyeongbuk, Pohang, 37673, South Korea
  18. 18. Centre for Materials Interfaces, Istituto Italiano di Tecnologia, Pisa, Pontedera, 56025, Italy
  19. 19. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Zhejiang, Quzhou, 324000, China
  20. 20. School of Chemistry, Damghan University, Damghan, 36716-41167, Iran

Source: Advanced Healthcare Materials Published:2022


Abstract

Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a variety of biomedical applications such as therapeutics delivery, cancer therapy, and tissue engineering. Physiochemical nanoparticle assembly techniques involve the application of solvents and potentially harmful chemicals, commonly at high temperatures. Genetically engineered organisms have the potential to be used as promising candidates for greener, efficient, and more adaptable platforms for the synthesis and assembly of nanomaterials. Genetically engineered carriers are precisely designed and constructed in shape and size, enabling precise control over drug attachment sites. The high accuracy of these novel advanced materials, biocompatibility, and stimuli-responsiveness, elucidate their emerging application in controlled drug delivery. The current article represents the research progress in developing various genetically engineered carriers. Organic-based nanoparticles including cellulose, collagen, silk-like polymers, elastin-like protein, silk-elastin-like protein, and inorganic-based nanoparticles are discussed in detail. Afterward, viral-based carriers are classified, and their potential for targeted therapeutics delivery is highlighted. Finally, the challenges and prospects of these delivery systems are concluded. © 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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