Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Comprehensive Insight Into the Effect of Berberine on Nonalcoholic Fatty Liver Disease (Nafld): A Systematic Review Publisher



Karimi A1 ; Vajdi M2 ; Sanaie S3 ; Akhlaghi S4 ; Negari A5 ; Dashti F6 ; Sefidmooye Azar P7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  2. 2. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Biomolecular Science, School of Pharmacy, University of Mississippi, Oxford, MS, United States
  5. 5. Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
  6. 6. Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  7. 7. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Food Biochemistry Published:2023


Abstract

Hepatic dysfunction is primarily caused by nonalcoholic fatty liver disease (NAFLD). Recently, berberine (BBR) has attracted researchers' interest with its hepatic protective property. A systematic review was conducted to evaluate the effects of BBR and its mechanisms of action in the management of NAFLD and its complications. The guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements were applied to perform the study. Embase, Web of Science, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus databases were searched up until March 2023. According to the inclusion criteria, finally, 65 studies were entered into the study. The evidence provided in the study revealed that BBR could regulate the development of NAFLD via several mechanisms of action namely lowering body weight, modulating lipid and glucose metabolism, and reducing inflammation and oxidative stress (OS). The current systematic review demonstrated the beneficial effects of BBR on NAFLD and its associated metabolic disorders including dyslipidemia, obesity, and insulin resistance through regulating lipid metabolism, facilitating β-oxidation of fatty acids, and mitigating the accumulation of triglycerides in hepatocytes. These beneficial effects make BBR a potential therapeutic approach and an efficient agent in the management of NAFLD and its related risk factors. There is an insufficient number of clinical trials addressing the effects of BBR in humans, so conducting more human research in the future is recommended. © 2023 Arash Karimi et al.
Related Docs
View other Related Docs
1. The Effect of Berberine Supplementation on Lipid Profile and Obesity Indices: An Umbrella Review of Meta-Analysis, PharmaNutrition (2023)
2. The Effects of Berberis Integerrima Fruit Extract on Glycemic Control Parameters in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2021)
3. The Effect of Curcumin Pill in Treatment of Non-Alcoholic Fatty Liver Disease: A Clinical Trial Study, Journal of Isfahan Medical School (2017)
4. Effect of Green Coffee Bean Extract Supplementation on Liver Function and Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Clinical Practice (2021)
5. The Effects of Ethanol Extract of Berberis Vulgaris Fruit on Histopathological Changes and Biochemical Markers of the Liver Damage in Diabetic Rats, Iranian Journal of Basic Medical Sciences (2017)
6. Efficacy of Synbiotic Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials: Synbiotic Supplementation and Nafld, Critical Reviews in Food Science and Nutrition (2019)
7. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
8. Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus, Revista Brasileira de Farmacognosia (2021)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (24)
Peyman Adibi (9)
Other Related Docs
9. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
10. Bilirubin, a Hepatoprotective Agent That Activates Sirt1, Pgc-1Α, And Ppar-Α, While Inhibiting Nf-Κb in Rats With Metabolic-Associated Fatty Liver Disease, Scientific Reports (2024)
11. The Effects of Curcumin Supplementation on Liver Function, Metabolic Profile and Body Composition in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
12. Effect of Sour Tea Supplementation on Liver Enzymes, Lipid Profile, Blood Pressure, and Antioxidant Status in Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Clinical Trial, Phytotherapy Research (2021)
13. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
14. Barberry (Berberis Vulgaris): Composition and Use of Extracts in Cancer Studies, Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer (2023)
15. Obesity and Air Pollution: Global Risk Factors for Pediatric Non-Alcoholic Fatty Liver Disease, Hepatitis Monthly (2011)
16. The Effects of Fasting Diets on Nonalcoholic Fatty Liver Disease, Nutrition Reviews (2023)
17. Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial, Diabetes, Metabolic Syndrome and Obesity (2020)
18. The Effects of Sumac (Rhus Coriaria L.) Powder Supplementation in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial, Complementary Therapies in Clinical Practice (2020)
19. Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group, Journal of Isfahan Medical School (2016)
20. Probiotics As a Novel Treatment for Non-Alcoholic Fatty Liver Disease; a Systematic Review on the Current Evidences, Hepatitis Monthly (2013)
21. The Effects of Zinc Supplementation on Metabolic Profile and Oxidative Stress in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Trace Elements in Medicine and Biology (2020)
22. Effect of Garlic Powder Supplementation on Blood Pressure and Hs-C-Reactive Protein Among Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Food Science and Nutrition (2021)
23. Does Nano-Curcumin Supplementation Improve Hematological Indices in Critically Ill Patients With Sepsis? a Randomized Controlled Clinical Trial, Journal of Food Biochemistry (2022)
24. Insulin-Like Growth Factor Binding Protein 3 Promoter Variant (Rs2854744) Is Associated With Nonalcoholic Fatty Liver Disease, Archives of Endocrinology and Metabolism (2023)
25. The Effects of Metformin Administration on Liver Enzymes and Body Composition in Non-Diabetic Patients With Non-Alcoholic Fatty Liver Disease And/Or Non-Alcoholic Steatohepatitis: An Up-To Date Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
26. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
27. Sustained Feeding of a Diet High in Fat Resulted in a Decline in the Liver's Insulin-Degrading Enzyme Levels in Association With the Induction of Oxidative and Endoplasmic Reticulum Stress in Adult Male Rats: Evaluation of 4-Phenylbutyric Acid, Heliyon (2024)
28. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
29. The Effects of Ursodeoxycholic Acid on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Cardiovascular Disorders (2025)
30. Effects of Cardamom Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Phytotherapy Research (2020)
31. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
32. The Effect of Zinc Supplementation on Steatosis Severity and Liver Function Enzymes in Overweight/Obese Patients With Mild to Moderate Non-Alcoholic Fatty Liver Following Calorie-Restricted Diet: A Double-Blind, Randomized Placebo-Controlled Trial, Biological Trace Element Research (2020)
33. Effects of Therapeutic Lifestyle Change Diets on Blood Lipids, Lipoproteins, Glycemic Parameters, and Blood Pressure: A Systematic Review and Meta-Analysis of Clinical Trials, Nutrition Reviews (2024)
34. Investigation of the Relationship Between Mir-33A, Mir-122, Erythrocyte Membrane Fatty Acids Profile, and Serum Lipids With Components of Metabolic Syndrome in Type 2 Diabetic Patients, Research in Pharmaceutical Sciences (2022)
35. The Effect of Ginger Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Clinical Trials, Phytomedicine (2018)
36. The Effect of a Mediterranean Diet on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
37. Efficacy of Curcumin Plus Piperine Co-Supplementation in Moderate-To-High Hepatic Steatosis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Phytotherapy Research (2023)
38. The Effect of Curcumin on Anthropometric Indices, Blood Pressure, Lipid Profiles, Fasting Blood Glucose, Liver Enzymes, Fibrosis, and Steatosis in Non-Alcoholic Fatty Livers, Frontiers in Nutrition (2023)
39. Effects of the Mixture of Melissa Officinalis L., Cinnamomum Zeylanicutn and Urtica Dioica on Hepatic Enzymes Activity in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Pharmacology (2012)
40. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
41. Nigella Sativa in Controlling Type 2 Diabetes, Cardiovascular, and Rheumatoid Arthritis Diseases: Molecular Aspects, Journal of Research in Medical Sciences (2021)
42. Treatment of Non-Alcoholic Fatty Liver Disease With Curcumin: A Randomized Placebo-Controlled Trial, Phytotherapy Research (2016)
43. The Role of Omega-3 Fatty Acids on the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease: A Review of Published Papers, Journal of Isfahan Medical School (2014)
44. The Effect of Psyllium on Anthropometric Measurements and Liver Enzymes in Overweight or Obese Adults With Nonalcoholic Fatty Liver Disease (Nafld), Journal of Isfahan Medical School (2015)
45. Dietary Choline and Betaine Intakes and Risk of Cardiovascular Diseases: Review of Epidemiological Evidence, ARYA Atherosclerosis (2011)
46. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
47. Comparative Study of Berberis Vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats, Iranian Journal of Pharmaceutical Research (2011)
48. The Effect of Vitamin D Supplementation on Insulin Resistance in Patients With Nonalcoholic Fatty Liver, Journal of Isfahan Medical School (2015)
49. The Effect of Vitamin D Supplementation on Blood Sugar and Different Indices of Insulin Resistance in Patients With Non-Alcoholic Fatty Liver Disease (Nafld), Iranian Journal of Nursing and Midwifery Research (2016)
50. The Effect of Sesame Oil Consumption Compared to Sunflower Oil on Lipid Profile, Blood Pressure, and Anthropometric Indices in Women With Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind Controlled Trial, Trials (2022)