Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Sour Tea Supplementation on Liver Enzymes, Lipid Profile, Blood Pressure, and Antioxidant Status in Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Clinical Trial Publisher Pubmed



Izadi F1 ; Farrokhzad A2 ; Tamizifar B3 ; Tarrahi MJ4 ; Entezari MH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Orthopedics, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Gastroenterology and Hepatology Research Center (lGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2021


Abstract

The aim of this study was to evaluate the efficacy of sour tea supplementation in patients with nonalcoholic fatty liver disease (NAFLD). Seventy NAFLD patients were enrolled in this randomized, double-blind, placebo-controlled clinical trial. Participants received sour tea in the form of a 450 mg capsule or a placebo capsule daily for 8 weeks. Anthropometric indices, liver enzymes, lipid profile, blood pressure, and antioxidant status were evaluated at the baseline and at the end of the study. Sixty-one participants completed the study. After 8 weeks, sour tea administration significantly decreased serum triglyceride (TG) (p =.03), alanine aminotransferase (ALT) (p =.01), and aspartate aminotransferase (AST) (p =.004) levels compared with the placebo. In addition, sour tea supplementation resulted in a significant reduction in systolic blood pressure (SBP) (p =.03) and diastolic blood pressure (DBP) (p =.04), and a significant increase in serum total antioxidant capacity (TAC) levels (p ˂.001) compared with the placebo. However, no significant changes in anthropometric measures, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) levels were observed after sour tea supplementation compared with the placebo (p >.05). Sour tea supplementation may be effective in improving serum TG, liver enzymes, and blood pressure in patients diagnosed with NAFLD. Further studies are needed to address the exact mechanism of action of these effects. © 2020 John Wiley & Sons Ltd
Related Docs
View other Related Docs
1. The Efficacy of Sour Tea (Hibiscus Sabdariffa L.) on Selected Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Phytotherapy Research (2020)
2. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Preventive Medicine (2015)
3. A Comparative Study of the Effect of Green Tea and Sour Tea on Blood Pressure and Lipid Profile in Healthy Adult Men, ARYA Atherosclerosis (2017)
4. The Effect of Curcumin Pill in Treatment of Non-Alcoholic Fatty Liver Disease: A Clinical Trial Study, Journal of Isfahan Medical School (2017)
5. Effect of Green Coffee Bean Extract Supplementation on Liver Function and Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Clinical Practice (2021)
6. Adherence to Low Carbohydrate Diets and Non-Alcoholic Fatty Liver Disease: A Case Control Study, BMC Nutrition (2022)
7. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
8. The Effect of Grape Products on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2022)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (39)
Awat Feizi (22)
Other Related Docs
9. The Efficacy of Vitamin D Supplementation Against Nonalcoholic Fatty Liver Disease: A Meta-Analysis, Journal of Dietary Supplements (2020)
10. The Effect of Green Tea and Sour Tea (Hibiscus Sabdariffa L.) Supplementation on Oxidative Stress and Muscle Damage in Athletes, Journal of Dietary Supplements (2017)
11. Effect of a Moderately Carbohydrate-Restricted Diet on Liver Enzymes, Steatosis and Fibrosis in Normal-Weight Individuals With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Parallel Randomised Controlled Clinical Trial, BMJ Open (2023)
12. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
13. Effects of a Novel Therapeutic Diet on Liver Enzymes and Coagulating Factors in Patients With Non-Alcoholic Fatty Liver Disease: A Parallel Randomized Trial, Nutrition (2014)
14. The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials, British Journal of Nutrition (2024)
15. Effect of Green Tea on Plasma Adiponectin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Journal of the American College of Nutrition (2017)
16. Efficacy of Synbiotic Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials: Synbiotic Supplementation and Nafld, Critical Reviews in Food Science and Nutrition (2019)
17. The Association Between the Dietary Inflammatory Index (Dii) and Some Serum Oxidative Stress Markers in Non-Alcoholic Fatty Liver Disease: Case-Control, International Journal of Preventive Medicine (2022)
18. Efficacy of Resveratrol Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Complementary Therapies in Clinical Practice (2021)
19. The Effects of Cynara Scolymus L. Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis, International Journal of Clinical Practice (2021)
20. The Effects of Low Carbohydrate Diets on Liver Function Tests in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Research in Medical Sciences (2016)
21. The Effect of Symbiotic Supplementation on Liver Enzymes, C‑Reactive Protein and Ultrasound Findings in Patients With Non‑Alcoholic Fatty Liver Disease: A Clinical Trial, International Journal of Preventive Medicine (2016)
22. The Association Between Major Dietary Patterns With the Risk of Non-Alcoholic Fatty Liver Disease, Oxidative Stress and Metabolic Parameters: A Case–Control Study, Journal of Diabetes and Metabolic Disorders (2022)
23. The Effect of Sesame Oil Consumption Compared to Sunflower Oil on Lipid Profile, Blood Pressure, and Anthropometric Indices in Women With Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind Controlled Trial, Trials (2022)
24. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
25. The Efficacy of Propolis on Markers of Glycemic Control in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Phytotherapy Research (2019)
26. A Comprehensive Insight Into the Effect of Berberine on Nonalcoholic Fatty Liver Disease (Nafld): A Systematic Review, Journal of Food Biochemistry (2023)
27. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
28. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
29. Effect of Garlic Powder Supplementation on Blood Pressure and Hs-C-Reactive Protein Among Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Food Science and Nutrition (2021)
30. The Effects of Curcumin Supplementation on Liver Function, Metabolic Profile and Body Composition in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
31. Evaluation of the Effects of Roselle (Hibiscus Sabdariffa L.) on Oxidative Stress and Serum Levels of Lipids, Insulin and Hs-Crp in Adult Patients With Metabolic Syndrome: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Complementary and Integrative Medicine (2016)
32. The Effects of Sumac (Rhus Coriaria L.) Powder Supplementation in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial, Complementary Therapies in Clinical Practice (2020)
33. Effects of Lacto-Ovo-Vegetarian Diet Vs. Standard-Weight-Loss Diet on Obese and Overweight Adults With Non-Alcoholic Fatty Liver Disease: A Randomised Clinical Trial, Archives of Physiology and Biochemistry (2023)
34. The Effects of Green Tea Supplementation on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2023)
35. Effect of Green Tea Extract on Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2020)
36. No Benefit of Soluble Fiber on Liver Function: A Systematic Review and Meta-Analysis of Controlled Trials, International Journal for Vitamin and Nutrition Research (2024)
37. Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group, Journal of Isfahan Medical School (2016)
38. Effects of Shrimp Oil on Cardio-Metabolic Risk Factors in Children and Adolescents, International Journal for Vitamin and Nutrition Research (2023)
39. Probiotics As a Novel Treatment for Non-Alcoholic Fatty Liver Disease; a Systematic Review on the Current Evidences, Hepatitis Monthly (2013)
40. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
41. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
42. The Effects of Zinc Supplementation on Metabolic Profile and Oxidative Stress in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Trace Elements in Medicine and Biology (2020)
43. Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-Alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial, International Journal of Preventive Medicine (2013)
44. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
45. Association of Dietary Patterns With Serum Vitamin D Concentration Among Iranian Adults With Abdominal Obesity, Clinical Nutrition Open Science (2021)
46. The Effects of Metformin Administration on Liver Enzymes and Body Composition in Non-Diabetic Patients With Non-Alcoholic Fatty Liver Disease And/Or Non-Alcoholic Steatohepatitis: An Up-To Date Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
47. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
48. Bilirubin, a Hepatoprotective Agent That Activates Sirt1, Pgc-1Α, And Ppar-Α, While Inhibiting Nf-Κb in Rats With Metabolic-Associated Fatty Liver Disease, Scientific Reports (2024)
49. Does Supplementation With Pine Bark Extract Improve Cardiometabolic Risk Factors? a Systematic Review and Meta-Analysis, BMC Complementary Medicine and Therapies (2025)
50. The Effect of Probiotics on Lipid Profile & Anthropometric Indices in Diabetic Nephropathy; a Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2021)