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The Effect of Dressing With Fresh Kiwifruit on Burn Wound Healing Publisher Pubmed



Mohajeri G1 ; Masoudpour H2 ; Heidarpour M3 ; Khademi EF4 ; Ghafghazi S7 ; Adibi S5 ; Akbari M6
Authors
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Authors Affiliations
  1. 1. Thoracic Surgery Department, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pathology Department, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Horticulture Department, Isfahan Faculty of Agriculture, Isfahan University of Technology, Isfahan, Iran
  5. 5. Veterinary Department of Torabinejad Experimental, Research Center, Isfahan University of Sciences, Isfahan, Iran
  6. 6. Isfahan University of Technology, Isfahan, Iran
  7. 7. Internal Medicine Department, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States

Source: Surgery Published:2010


Abstract

Background: This study was designed to evaluate the wound healing effects of kiwifruit in the treatment of second-degree burn wounds in rats. Methods: Sixty rats were each randomly assigned to 1 of 3 groups. A deep second-degree burn was created on the lateral flank of each rat with a standard burning procedure in the form of applying a heated plaque. In the control group (group C; n = 20) burns were dressed with Vaseline sterile gauze after normal saline irrigation. In group S (n = 20), the lesions were treated with silver sulfadiazine cream after normal saline irrigation. In the third group (group K; n = 20), the burn wounds were dressed with kiwifruit. The dressings were changed twice a day in all groups. The response to treatments was assessed histologically at day 21 postburn and microbiologically on days 7 and 21. Macroscopic evaluation was performed every day to determine wound closure rate, measure burn wound area, and investigate macroscopic edema, hyperemia, and epithelialization. Histopathologic evaluation included monitoring of epithelialization, vascularization, granulation tissue formation, and inflammatory cell response. Results: On day 21, the wounds in the group K healed completely in comparison to other groups (P < .0001). There was significant reduction in wound area size in the group K in all evaluation days as compared with groups S and C (P < .0001). Microscopic evaluation revealed a high grade of neovascularization in group K lesions in contrast with groups S and C (P < .0001). Wound infection was dramatically less common in the group K compared with the other 2 groups (P < .05). Conclusion: We suggest that the dramatic antibacterial, debridement, wound contracture, and angiogenic effect of kiwifruit induced a significant wound healing in burn ulcers and might be useful in treating chronic ulcers, such as bedsores. © 2010 Mosby, Inc. All rights reserved.
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