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The Effect of Quercus Brantii Gall Extract on Burn Wound Healing in Rat Publisher



Haghdoost F1, 2 ; Baradaran Mahdavi MM1 ; Zolfaghari B3 ; Sanei MH4 ; Najafi S2 ; Zandifar A1, 2 ; Manouchehri N1 ; Haghjooy Javanmard S2
Authors
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Authors Affiliations
  1. 1. Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, HezarJarib Ave., Isfahan, Iran
  4. 4. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Basic Medical Sciences Published:2016


Abstract

Objective(s): The aim of the present study was to evaluate the effect of Quercus brantii galls extract on the rat skin burn wound healing. Materials and Methods: Ethanol extract of the galls of Q. brantii was used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics. Results: The mean wound surface in the 14th day, in all groups treated by Q. brantii gall extracts were larger than control group and the differences were statistically significant (P=0.043). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the 5th day of study showed that there was not any significant difference between groups (P=0.468 and 0.312 respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with 1% gall extract gel in comparison to the control group (P=0.026). Conclusion: Our results could not prove the significant positive effect of Q. brantii galls extract on the burning wound healing. More studies with more groups treated with different doses of the Q. brantii extract are recommended. i¿½ 2016, Mashhad University of Medical Sciences. All rights reserved.
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