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The Potential Role of Protein Disulfide Isomerases (Pdis) During Parasitic Infections: A Focus on Leishmania Spp. Publisher Pubmed



Dousti M1 ; Hosseinpour M2 ; Ghasemi ND3 ; Mirfakhraee H1 ; Rajabi SK1 ; Rashidi S4, 5 ; Hatam G6
Authors
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Authors Affiliations
  1. 1. Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  3. 3. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran
  5. 5. Department of Medical Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran
  6. 6. Basic Sciences Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Pathogens and Disease Published:2023


Abstract

Leishmaniasis is a group of vector-borne diseases caused by intracellular protozoan parasites belonging to the genus Leishmania. Leishmania parasites can employ different and numerous sophisticated strategies, including modulating host proteins, cell signaling, and cell responses by parasite proteins, to change the infected host conditions to favor the parasite persistence and induce pathogenesis. In this sense, protein disulfide isomerases (PDIs) have been described as crucial proteins that can be modulated during leishmaniasis and affect the pathogenesis process. The effect of modulated PDIs can be investigated in both aspects, parasite PDIs and infected host cell PDIs, during infection. The information concerning PDIs is not sufficient in parasitology; however, this study aimed to provide data regarding the biological functions of such crucial proteins in parasites with a focus on Leishmania spp. and their relevant effects on the pathogenesis process. Although there are no clinical trial vaccines and therapeutic approaches, highlighting this information might be fruitful for the development of novel strategies based on PDIs for the management of parasitic diseases, especially leishmaniasis. © The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. All rights reserved.
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