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Low-Level Laser and Bovine Amniotic Fluid-Derived Cream Accelerating Skin Neck Wound Healing and Reducing Inflammation and Wound Scar in a Rat Animal Model Publisher



Abbasiazar D1 ; Mollazadehghomi S1, 2 ; Javadi A1, 3 ; Darabi S1, 2 ; Mollazadehghomi S1, 2 ; Abdali H1
Authors
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Authors Affiliations
  1. 1. Department of Surgery, School of Medicine, Esfahan University of Medical Sciences, Esfahan, Iran
  2. 2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  3. 3. School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  4. 4. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Cutaneous and Aesthetic Surgery Published:2022


Abstract

Background: Nowadays, wound healing is one of the main problems of patients. Therefore, extensive research is underway to discover mechanisms associated with non-scarring of wounds. Using amniotic fluid and laser may potentially play a key role in wound healing and scar reduction due to its presence in tissue growth and repair agents. Aim: The present study evaluated the effect of bovine amniotic fluid (BAF)-derived cream and low-power laser (LPL) on accelerating skin wound healing and reducing scarring in an animal model. Materials and Methods: Therefore, 72 male Wistar rats were randomly divided into three groups (each group: 24). A wound 6 mm in diameter was then inflicted on the rats' backs. In the first group that was the control group, the wound was only used. Moreover, BAF was implemented for the second group, and in the third group, LPL radiation was utilized. On the 1st, 3rd, 5th, 14th, and 21st days, the healing condition of the wound and scar created were examined. Results: Hence, evaluation of wound healing status on days 5 and 14 showed that the wound healing scale in the BAF group and LPL group was significantly better than that of the control group. On the 21st day, the average Scar Scoring Scale in the BAF and LPL groups was significantly lower than that of the control group. Histological images showed a significant repair in the LPL and BAF groups. Conclusion: To conclude, considering the positive effect of LPL and BAF on wound healing and less scarring, it seems that LPL and BAF can heal wounds faster. Moreover, they can be used to prevent scarring after wound healing. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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