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Wound Healing Activity of Pimpinella Anisum Methanolic Extract in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Hashemnia M1 ; Nikousefat Z3 ; Mohammadalipour A2 ; Zangeneh MM3, 4 ; Zangeneh A3, 4
Authors
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Authors Affiliations
  1. 1. Department of Pathobiology, Veterinary Medicine Faculty, Razi University, Kermanshah, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
  4. 4. Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

Source: Journal of Wound Care Published:2019


Abstract

Objective: To assess the wound healing potential of Pimpinella anisum on cutaneous wounds in diabetic rats. Method: Full-thickness excisional wounds were made on the back of male, Sprague-Dawley rats with diabetes. The rats were randomly allocated into four treatment groups: 1ml basal cream; tetracycline (3%); Pimpinella anisum 10% for 14 days; and a control group. At days seven, 14 and 21 post-injury, five animals of each group were euthanised, and wounds were assessed through gross, histopathological and oxidant/antioxidant evaluations. Additionally, the dry matter and hydroxyproline contents of the skin samples were measured. Results: A total of 60 rats were used in the study. A significant decrease in the wound size was observed in treated animals with Pimpinella anisum compared with other groups during the experiment. Additionally, treatment with Pimpinella anisum decreased the number of lymphocytes and improved the number of fibroblasts at the earlier stages and increased a number of fibrocytes at the later stages of wound healing. Other parameters such as re-epithelialisation, tissue alignment, greater maturity of collagen fibres and large capillary-sized blood vessels revealed significant changes when compared with the control. Pimpinella anisum significantly reverted oxidative changes of total antioxidant capacity, malondialdehyde and glutathione peroxidase induced by diabetic wounds (p<0.05). Furthermore, it significantly increased the dry matter and hydroxyproline contents at various stages of wound healing (p<0.05). Conclusion: The present study showed that application of Pimpinella anisum extract promotes wound healing activity in diabetic rats. The wound-healing property of Pimpinella anisum can be attributed to the phytoconstituents present in the plant. © 2019 MA Healthcare Ltd. All rights reserved.
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