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Efficacy of Low-Fat Milk and Yogurt Fortified With Vitamin D3 on Systemic Inflammation in Adults With Abdominal Obesity Publisher Pubmed



Sharifan P1, 2 ; Rashidmayvan M2 ; Khorasanchi Z1, 2 ; Darroudi S3 ; Heidari A4 ; Hoseinpoor F4 ; Vatanparast H5 ; Safarian M2 ; Eslami S6 ; Afshari A2 ; Asadi Z3 ; Ghazizadeh H1, 3 ; Bagherniya M7 ; Khedmatgozar H2, 8 Show All Authors
Authors
  1. Sharifan P1, 2
  2. Rashidmayvan M2
  3. Khorasanchi Z1, 2
  4. Darroudi S3
  5. Heidari A4
  6. Hoseinpoor F4
  7. Vatanparast H5
  8. Safarian M2
  9. Eslami S6
  10. Afshari A2
  11. Asadi Z3
  12. Ghazizadeh H1, 3
  13. Bagherniya M7
  14. Khedmatgozar H2, 8
  15. Ferns G9
  16. Rezaie M2
  17. Mobarhan MG2, 3
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran
  4. 4. Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
  5. 5. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
  6. 6. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, United States
  9. 9. Division of Medical Education, Brighton and Sussex Medical School, Brighton, United Kingdom

Source: Journal of Health, Population and Nutrition Published:2022


Abstract

Background: The prevalence of vitamin D deficiency is increasing globally and is associated with an increased risk of metabolic syndrome, autoimmune disease, and cardiovascular disease. Vit D deficiency is also associated with increased systemic inflammation. The current study aimed to determine the efficacy of low-fat milk and yogurt fortified with 1500 IU nano-encapsulated vitamin D, on systemic inflammation in abdominal obese participants. Method: This multi-center study was conducted using a 2.5-month parallel total-blind randomized clinical trial design. Two hundred and eighty nine subjects were allocated to four groups: low-fat milk fortified by 1500 IU nano-encapsulated vitamin D3 (200 mL/day). Simple milk (200 mL/day), low-fat yogurt fortified by 1500 IU nano-encapsulated vitamin D3 (150 g/day), and simple yogurt (150 g/day). Results: The results showed that serum levels of neutrophils, lymphocytes, platelets and red blood cell distribution width (RDW) were significantly lower before and after the intervention in fortified dairy groups. The results showed that serum levels of neutrophils, lymphocytes, platelets, and RDW before and after intervention in the fortified dairy groups were significantly lower (p < 0.05). The values of = neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio, and RDW to platelets ratio (RPR) reduced significantly in the fortification group (p < 0.05). Conclusion: Fortification with nano-encapsulated vitamin D3 of dairy products may decrease inflammation in individuals with abdominal obesity. © 2022, The Author(s).
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