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The Effects of Consuming a Low-Fat Yogurt Fortified With Nano Encapsulated Vitamin D on Serum Pro-Oxidant-Antioxidant Balance (Pab) in Adults With Metabolic Syndrome; a Randomized Control Trial Publisher Pubmed



Taghizadeh N1 ; Sharifan P2, 4 ; Ekhteraee Toosi MS1 ; Najar Sedgh Doust F1 ; Darroudi S3 ; Afshari A2 ; Rezaie M2 ; Safarian M2 ; Vatanparast H5 ; Eslami S6 ; Ghazizadeh H3, 4 ; Khorasanchi Z2 ; Bagherniya M7 ; Ferns G8 Show All Authors
Authors
  1. Taghizadeh N1
  2. Sharifan P2, 4
  3. Ekhteraee Toosi MS1
  4. Najar Sedgh Doust F1
  5. Darroudi S3
  6. Afshari A2
  7. Rezaie M2
  8. Safarian M2
  9. Vatanparast H5
  10. Eslami S6
  11. Ghazizadeh H3, 4
  12. Khorasanchi Z2
  13. Bagherniya M7
  14. Ferns G8
  15. Assaran Darban R1
  16. Ghayourmobarhan M2, 3
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  2. 2. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
  6. 6. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Brighton and Sussex Medical School, Division of Medical Education, Brighton, United Kingdom

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2021


Abstract

Background and aim: The current study aimed to assess the effect of fortified yogurt with nano-encapsulated vitamin D on serum pro-oxidant anti-oxidant balance (PAB) in adults with or without metabolic syndrome. Methods: In a quadruple blind clinical trial study, 139 adults with an age range of 30–50 years were randomly selected to receive either 1500 IU nano-encapsulated vitamin D fortified yogurt or placebo for ten weeks. Before and after the intervention period, blood sample was taken to determine the serum levels of vitamin D, pro-oxidant-antioxidant balance (PAB), and high-sensitivity C-reactive protein (hs-CRP). The laboratory tests were checked at baseline and at the end of the treatment. Results: Serum vitamin D increased significantly, from 14.47 ± 6.07 ng/mL to 21.39 ± 6.54 ng/mL (P < 0.001) after ten weeks in the intervention group. Serum hs-CRP and PAB were significantly lower following consumption period in intervention group [1.95(0.4–8.15) g/dL vs. 1.35(0.25–3.62) g/dL; P = 0.013] and (135.19 ± 42.4 HK vs. 115.39 ± 44.69) HK; P = 0.018] respectively. There were no significant differences between the intervention and control groups regarding weight and BMI at the end of the intervention period (p > 0.05). Conclusion: Low-fat yogurt fortified with nano-encapsulated vitamin D was found to reduce serum PAB levels in adults with metabolic syndrome. Practical application: The findings of the present study indicated that a low-fat yogurt fortified with 1500 IU nano-encapsulated vitamin D for ten weeks, leads to a significant reduction in serum hs-CRP and PAB concentrations highlighted the anti-inflammatory/anti-oxidative effect of vitamin D. © 2021 Diabetes India
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