Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Protective Effects of Ziziphus Vulgaris L. Fruits on Biochemical and Histological Abnormalities Induced by Diabetes in Rats Publisher Pubmed



Golimalekabadi N1 ; Asgary S1 ; Rashidi B2 ; Rafieiankopaei M3 ; Ghannadian M4 ; Hajian S1 ; Sahebkar A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Department of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Complementary and Integrative Medicine Published:2014


Abstract

Background: Diabetes mellitus arises from a deficient production and action of insulin. Ziziphus vulgaris L. (jujube) is a medicinal plant that is known to have antidiabetic actions. The aim of the present study was to investigate the protective effects of jujube fruit powder and extract against biochemical imbalances in stereptozotocin (STZ)-induced diabetes. Methods: Diabetes was induced in rats using intraperitoneal injection of STZ at a dose of 60 mg/kg body weight (bw). Jujube powder (1 g/kg bw) and extract (1 g/kg bw) were administered daily via gavage, from two weeks prior to three weeks after STZ injection. Serum concentrations of glucose, insulin, and lipids and histological changes of the pancreas tissue were assessed at the end of study. Results: The kaempferol content of jujube extract was found to be 0.013±0.0005% (w/w). Two weeks of supplementation with jujube powder resulted in a significant reduction of serum glucose levels compared with the non-diabetic control group prior to STZ treatment. Both jujube preparations prevented serum insulin decrease following STZ treatment, increased antioxidant capacity, and reduced total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde levels. Jujube powder reduced serum low-density lipoprotein cholesterol and C-reactive protein concentrations while jujube extract had no effect on these parameters. Histopathological examination revealed a significant attenuation of pancreatic inflammation in the jujube-treated animals. Conclusions: The present findings suggest a protective role of jujube supplementation, in particular in the powdered form, against diabetes-induced biochemical and histopathological abnormalities. © 2014 Walter de Gruyter GmbH, Berlin/Boston.
Related Docs
View other Related Docs
1. Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Vaccinium Myrtillus Fruit in Experimentally Induced Diabetes (Antidiabetic Effect of Vaccinium Myrtillus Fruit), Journal of the Science of Food and Agriculture (2016)
2. Protective and Therapeutic Effects of Phoenix Dactylifera Leaf Extract on Pancreatic Β-Cells and Diabetic Parameters in Streptozotocin-Induced Diabetic Rats, Comparative Clinical Pathology (2020)
3. Preventive Effect of Pumpkin (Cucurbita Pepo L.) on Diabetic Index and Histopathology of Pancreas in Alloxan-Induced Diabetes in Rats, Journal of Isfahan Medical School (2011)
4. Effect of Hydroalcoholic and Buthanolic Extract of Cucumis Sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats, Iranian Journal of Basic Medical Sciences (2011)
5. Effects of Salvia Mirzayanii Extract Administration on Hyperglycemia Improvement in Diabetic Rats: The Role of Glut4, Pepck and G6pase Genes, Heliyon (2024)
6. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
7. Effects of Berberis Vulgaris Fruit Extract on Oxidative Stress Status in the Kidney and Liver of Diabetic Rats, Journal of Complementary and Integrative Medicine (2024)
8. Anti-Diabetic Effects of Walnut Oil on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (17)
Nepton Soltani (17)
Other Related Docs
9. Effect of the Administration of Solanum Nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats, Pharmacognosy Research (2017)
10. Effect of Long-Term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: The Role of Akt2 and Irs1 Gene Expressions, Biological Trace Element Research (2019)
11. Evaluation of the Effects of Cornus Mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2015)
12. Effects of Cornus Mas L. on Blood Glucose, Insulin and Histopathology of Pancreas in Alloxan-Induced Diabetic Rats, Journal of Isfahan Medical School (2011)
13. Hypoglycaemic and Hypolipidemic Effects of Pumpkin (Cucurbita Pepo L.) on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
14. The Effects of Ethanol Extract of Berberis Vulgaris Fruit on Histopathological Changes and Biochemical Markers of the Liver Damage in Diabetic Rats, Iranian Journal of Basic Medical Sciences (2017)
15. Effect of Ethanolic Extract of Juglans Regia L. on Blood Sugar in Diabetes-Induced Rats, Journal of Medicinal Food (2008)
16. Renal Biochemical and Histopathological Alterations of Diabetic Rats Under Treatment With Hydro Alcoholic Morus Nigra Extract, Journal of Renal Injury Prevention (2017)
17. Antihyperlipidemic Effect of Peucedanum Pastinacifolium Extract in Streptozotocin-Induced Diabetic Rats, Clinics (2010)
18. Effects of Methanolic and Butanolic Fractions of Allium Elburzense Wendelbo Bulbs on Blood Glucose Level of Normal and Stz-Induced Diabetic Rats, Research in Pharmaceutical Sciences (2012)
19. Effect of Hordeum Vulgare L. (Barley) on Blood Glucose Levels of Normal and Stz-Induced Diabetic Rats, Research in Pharmaceutical Sciences (2014)
20. The Effects of Aqueous Extract of Alfalfa on Blood Glucose and Lipids in Alloxan-Induced Diabetic Rats, Interventional Medicine and Applied Science (2015)
21. Effect of the Hydroalcoholic Extract and Juice of Prunus Divaricata Fruit on Blood Glucose and Serum Lipids of Normal and Streptozotocin Induced Diabetic Rats, Research in Pharmaceutical Sciences (2014)
22. Biochemical and Histopathological Study of the Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Cornelian Cherry (Cornus Mas L.) in Alloxan-Induced Diabetic Rats, Journal of Complementary and Integrative Medicine (2014)
23. Effects of Securigera Securidaca Extract on Lipolysis and Adipogenesis in Diabetic Rats, Cholesterol (2014)
24. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)
25. The Nephroprotective Effect of Eryngium Caucasicum Extract Alone and in Combination With Metformin in Adult Male Diabetic Rats, Journal of Nephropharmacology (2023)
26. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
27. Preparation and Evaluation of a Controlled Drug Release of Repaglinide Through Matrix Pellets: In Vitro and in Vivo Studies, Journal of Microencapsulation (2014)
28. Trans-Differentiation of Mouse Mesenchymal Stem Cells Into Pancreatic Β-Like Cells by a Traditional Anti-Diabetic Medicinal Herb Medicago Sativa L, Journal of Traditional and Complementary Medicine (2022)
29. Therapeutic Effect of Fenugreek Supplementation on Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
30. Evaluating the Liver Toxicity of Hydroalcoholic Extract of Momordica Charantia in Male Balb/C Mice, Journal of Isfahan Medical School (2016)
31. Diosgenin Mitigates Streptozotocin Diabetes-Induced Vascular Dysfunction of the Rat Aorta: The Involved Mechanisms, Journal of Cardiovascular Pharmacology (2015)
32. Long-Term Gaba Supplementation Regulates Diabetic Gastroenteropathy Through Gaba Receptor/Trypsin-1/Pars/Akt/Cox-2 Axis, Doklady Biochemistry and Biophysics (2024)
33. Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat, Iranian Biomedical Journal (2003)
34. Effect of Magnesium Sulfate Administration to Improve Insulin Resistance in Type 2 Diabetes Animal Model: Using the Hyperinsulinemic-Euglycemic Clamp Technique, Fundamental and Clinical Pharmacology (2018)
35. Effect of Oral Administration of Magnesium on Cisplatin-Induced Nephrotoxicity in Normal and Streptozocin-Induced Diabetic Rats, Nephro-Urology Monthly (2013)
36. Effect of Oral Magnesium Sulfate Administration on Blood Glucose Hemostasis Via Inhibition of Gluconeogenesis and Foxo1 Gene Expression in Liver and Muscle in Diabetic Rats, Biomedicine and Pharmacotherapy (2019)
37. The Inhibitory Effects of Pure Flavonoids on in Vitro Protein Glycosylation, Journal of Herbal Pharmacotherapy (2002)
38. Antidiabetic Effect of Hydroalcoholic Extract of Carthamus Tinctorius L. in Alloxan-Induced Diabetic Rats, Journal of Research in Medical Sciences (2012)
39. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Koomesh (2023)
40. The Effect of Phytochemicals in Prediabetic Patients: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)
41. The Effect of Rosa Damascena Extract on Blood Glucose and Insulin Levels in Diabetic Rats, Journal of Isfahan Medical School (2020)
42. Magnesium Sulfate Improves Insulin Resistance in High Fat Diet Induced Diabetic Parents and Their Offspring, European Journal of Pharmacology (2021)
43. Does Fenugreek (Trigonella Foenum-Graecum) Seed Improve Inflammation, and Oxidative Stress in Patients With Type 2 Diabetes Mellitus? a Parallel Group Randomized Clinical Trial, European Journal of Integrative Medicine (2018)
44. Long Term Effects of Oral Vitamin E Supplement in Type Ii Diabetic Patients, International Journal for Vitamin and Nutrition Research (2005)
45. The Effect of Grapes/Grape Products on Glycemic Response: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
46. Preparation and Characterisation of a New Form of Silymarin As a Potential Antidiabetic Agent in the Adult Male Rat, Archives of Physiology and Biochemistry (2023)
47. Salsalate Efficacy in Blood Glucose Level Reduction in Diabetes, Journal of Isfahan Medical School (2009)
48. The Effects of Jujube (Ziziphus Jujube) on Metabolic and Mental Health Outcomes in Patients With Metabolic Syndrome: A Randomized Controlled Trial, Complementary Therapies in Medicine (2024)
49. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Biomedicine and Pharmacotherapy (2021)
50. Applying the Taguchi Design for Optimized Formulation of Sustained Release Gliclazide Chitosan Beads: An in Vitro/In Vivo Study, AAPS PharmSciTech (2009)