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Abnormal Liver Enzymes in Coal Tar Refinery Workers of Isfahan



Tavakkoli H1 ; Ghaemmaghami Z2 ; Emami MH1 ; Adibi P1 ; Galedari H3 ; Haghighi M4 ; Gholamrezaei A5
Authors
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Authors Affiliations
  1. 1. Department of Gastroenterology and Hepatology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. General Practitioner, Occupational Medicine Unit, Isfahan Steel Company, Isfahan, Iran
  4. 4. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Poursina Hakim Research Institute, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: The effects of occupational exposure on liver function in oil refinery workers are not well known. In this study we evaluated the liver enzyme abnormalities among coal tar refinery workers. Methods: The oil refinery workers in central part of Iran (Isfahan city) underwent routine annual medical examination from 2006 to 2007. A total of 66 cases with abnormal levels of aminotransferases were included in this cross-sectional study. Liver diseases including viral, metabolic and autoimmune hepatitis were excluded by detailed investigations. The relationships of different findings and liver enzymes were evaluated through inferential statistics. Findings: All patients were male with the mean age of 36.7 ± 4.8 years. Thirty eight subjects had dys-lipidemia (61.3%). There were significant correlations between triglyceride or cholesterol concentrations and aminotransferases levels. From 40 cases, 35 cases (87.5%) demonstrated ultrasonographic fatty livers. Also, significant correlations were found between cholesterol and Gamma-glutamyl trans-peptidase (GGT) levels. There were not significant differences in levels of aminotransferases among different type of work (P > 0.05). Conclusion: Direct occupational exposure to oil refinery products may play an important role in liver enzyme abnormalities. Exposure to coal tar components such as phenols, poly aromatic hydrocarbons chemicals may be a risk factor for NASH (Non-alcoholic Steato-hepatitis). Liver biopsy and long term follow-up can be helpful for definite diagnosis and determination of prognosis.
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