Association of Hypertriglyceridemic-Waist Phenotype With Liver Enzymes and Cardiometabolic Risk Factors in Adolescents: The Caspian-Iii Study; [Associacao Do Fenotipo De Cintura Hipertrigliceridemica Com Enzimas Hepaticas E Fatores De Risco Cardiometabolico Em Adolescentes: O Estudo Caspian-Iii] Publisher Pubmed



Kelishadi R¹ ; Jamshidi F¹ ; Qorbani M^{2, 3} ; Motlagh ME⁴ ; Heshmat R³ ; Ardalan G¹ ; Hovsepian S¹ Show Affiliations
Source: Jornal de Pediatria Published:2016

Abstract

Objective This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic-waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. Method This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10–18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined. Results The mean age of studied population was 14.73 ± 2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty-nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with HW phenotype and MetS than in their peers (p < 0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL-C (p < 0.05). Conclusions The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders. © 2016