Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study Publisher Pubmed



Tajadod S1 ; Shekari S2 ; Khalatbari Mohseni G3 ; Abbasi K4 ; Torki SA5 ; Salimi Z3 ; Keshavarz Mohammadian M2 ; Shapouri M6 ; Jarrahi SAM7 ; Sobhani Far F8 ; Shafaei H9 ; Doaei S10 ; Moghadam HY11 ; Gholamalizadeh M12
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School Of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Nursing and Midwifery School, Guilan University of Medical Sciences, Rasht, Iran
  10. 10. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Iranian Research Center on Healthy Aging, Operating Room Department, Faculty of Paramedics, Sabzevar University of Medical Sciences, Sabzevar, Iran
  12. 12. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Nutrition ESPEN Published:2023


Abstract

Background: The effect of dietary fats on type 2 diabetes (T2D) is not clear. This study aimed to determine the association between T2D and dietary fatty acids among Iranian adults. Methods: This case–control study was performed on 4241 participants aged 35–70, including 1804 people with T2D and pre-diabetes as the case group and 2437 people without diabetes as the control group. Dietary intake was assessed using a food frequency questionnaire (FFQ). Results: The cases had higher age (48.36 ± 8.62 vs. 54.53 ± 7.75 y, P < 0.001), weight (73.7713.41 vs. 76.18 ± 13.49 kg, P = 0.001), body mass index (BMI) (28.02 ± 4.70 vs. 24 ± 4.74 kg/m2, P = 0.001), right systolic blood pressure (RSBP) (113.33 ± 16.7 vs. 121.61 ± 17.24 mmHg, P = 0.001), right diastolic blood pressure (RDBP) (71.41 ± 10.53 vs. 75.33 ± 9.92 mmHg, P = 0.001), fasting blood sugar (FBS) (96.87 ± 19.39 vs. 169.95 ± 69.28 mg/dl, P = 0.001), blood urine nitrogen (BUN) (13.65 ± 3.74 vs. 14.26 ± 4.03 mg/dl, P = 0.001), triglyceride (TG) (141.61 ± 99.37 vs. 175.96 ± 114.74 mg/dl, P = 0.001), alkaline phosphatase (ALP) (218.24 ± 66.35 vs. 246.97 ± 72.65 IU/L, P = 0.001), low-density lipoprotein cholesterol (LDL) (111.68 ± 33.02 vs. 101.97 ± 36.54 mg/dl, P = 0.001), serum glutamic-pyruvic transaminase (SGPT) (21.88 ± 15.15 vs. 23.55 ± 15.96 IU/L, P = 0.001), gamma-glutamyl transferase (GGT) (24.66 ± 20.42 vs. 30.72 ± 30.43 IU/L P = 0.001), and cholesterol (192.45 ± 39.1190 vs. 187.12 ± 46.19 mg/dl P = 0.001) compared to the control group. T2D was negatively associated with dietary intake of PUFAs (OR = 0.93, CI95%:0.84–1.03, P = 0.01) and positively associated with dietary cholesterol (OR: 1.01, CI95%:1.001–1.01, P = 0.02). Conclusion: In summary, cholesterol was positively and PUFAs were negatively associated with diabetes. If the results of the present study on the effect of fat intake on diabetes are proven, future dietary recommendations for people at risk of diabetes may be corrected by providing diets rich in polyunsaturated fatty acids and low in cholesterol. © 2023
Related Docs
View other Related Docs
1. Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematireview and Dose-Response Meta-Analysis of Prospective Cohort Studies, Diabetes Care (2021)
2. Relationship Between Dietary Patterns and Incidence of Type 2 Diabetes, International Journal of Preventive Medicine (2019)
3. Association of Ultra-Processed Food Consumption With Cardiovascular Risk Factors Among Patients With Type-2 Diabetes Mellitus, Nutrition and Diabetes (2024)
4. The Association Between Types of Seafood Intake and the Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Health Promotion Perspectives (2019)
5. Anthropometric Indices Predicting Incident Type 2 Diabetes in an Iranian Population: The Isfahan Cohort Study, Diabetes and Metabolism (2013)
6. Dietary Acid Load and Its Interaction With Cetp Taqb1 Polymorphisms on Lipid Profile Among Patients With Type 2 Diabetes Mellitus, BMC Endocrine Disorders (2023)
7. The Effect of Nutrition Education on Risk Factors of Cardiovascular Diseases in Elderly Patients With Type 2 Diabetes: A Randomized Controlled Trial, Iranian Journal of Endocrinology and Metabolism (2011)
8. Dietary Insulin Index and Load and Cardiometabolic Risk Factors Among People With Obesity: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (173)
Nizal Sarrafzadegan (139)
Other Related Docs
9. Effects of Dietary Energy Density on Serum Adipocytokine Levels in Diabetic Women, Hormone and Metabolic Research (2013)
10. Utility of Hypertriglyceridemic Waist Phenotype for Predicting Incident Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Journal of Diabetes Investigation (2016)
11. Metabolic Syndrome in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Metabolic Syndrome and Related Disorders (2007)
12. How Is Healthy Eating Index-2015 Related to Risk Factors for Cardiovascular Disease in Patients With Type 2 Diabetes, Frontiers in Nutrition (2023)
13. Role of Dietary N-3 Polyunsaturated Fatty Acids in Type 2 Diabetes: A Review of Epidemiological and Clinical Studies, Maturitas (2013)
14. Dietary Fat Intake and Lipid Profiles of Iranian Adolescents: Isfahan Healthy Heart Program-Heart Health Promotion From Childhood, Preventive Medicine (2004)
15. Food Intake Patterns May Explain the High Prevalence of Cardiovascular Risk Factors Among Iranian Women, Journal of Nutrition (2008)
16. The Relationship Between Diet Quality Index and Components of Metabolic Syndrome, Journal of Health System Research (2024)
17. Interaction Between Cetp Taq1b Polymorphism and Hei, Dqi and Dpi on Metabolic Biomarkers in Patients With Type 2 Diabetes, Journal of Human Nutrition and Dietetics (2022)
18. Dietary Acid Load and Risk of Type 2 Diabetes Mellitus: A Case–Control Study, Clinical Nutrition ESPEN (2022)
19. Association of Dietary Fats With Ischemic Heart Disease (Ihd): A Case–Control Study, Journal of Health, Population and Nutrition (2024)
20. Associations of Fruit and Vegetable Intake With Metabolic Health Status in Overweight and Obese Youth, Annals of Nutrition and Metabolism (2023)
21. Association Between Dietary Insulin Index and Load With Obesity in Adults, European Journal of Nutrition (2020)
22. Evaluation of the Effects of Dietary Energy Density on Anthropometric and Glycemic Indices and Lipid Profile in Women With Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2012)
23. Different Kinds of Vegetable Oils in Relation to Individual Cardiovascular Risk Factors Among Iranian Women, British Journal of Nutrition (2011)
24. Healthy Eating Index and Cardiovascular Risk Factors Among Iranians, Journal of the American College of Nutrition (2013)
25. Association Between Ultra-Processed Foods Intake With Lipid Profile: A Cross-Sectional Study, Scientific Reports (2023)
26. Consumption of Energy-Dense Diets in Relation to Cardiometabolic Abnormalities Among Iranian Women, Public Health Nutrition (2012)
27. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
28. Longitudinal Association of Dietary Fat Intake With Cardiovascular Events in a Prospective Cohort Study in Eastern Mediterranean Region, International Journal of Food Sciences and Nutrition (2021)
29. The Effect of Walnut Consumption on Lipid Profiles of the First-Degree Relatives of Type Two Diabetes Mellitus Patients (T2dm) With Prediabetes, Pakistan Journal of Medical Sciences (2013)
30. Dietary Energy Density and the Metabolic Syndrome Among Iranian Women, European Journal of Clinical Nutrition (2011)
31. Interaction Between Cetp Polymorphism and Dietary Insulin Index and Load in Relation to Cardiovascular Risk Factors in Diabetic Adults, Scientific Reports (2021)
32. The Association Between Dietary Habits and Metabolic Syndrome: Findings From the Shahedieh-Cohort Study, BMC Nutrition (2022)
33. Longitudinal Association of Metabolic Syndrome and Dietary Patterns: A 13-Year Prospective Population-Based Cohort Study, Nutrition, Metabolism and Cardiovascular Diseases (2018)
34. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
35. Study of Saturated Fatty Acids in Different Traditional Foods Distributed in Isfahan, Iran, Journal of Health System Research (2020)
36. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
37. Healthy and Unhealthy Dietary Patterns Are Related to Pre-Diabetes: A Case-Control Study, British Journal of Nutrition (2016)
38. Determinants of Central Adiposity: An Iranian Perspective, Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease (2012)
39. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
40. The Relationship Between Low-Carbohydrate Diet Score, Dietary Insulin Index and Load With Obesity in Healthy Adults, Eating and Weight Disorders (2022)
41. Burden of Ischemic Heart Disease Attributable to Low Omega-3 Fatty Acids Intake in Iran: Findings From the Global Burden of Disease Study 2010, Journal of Tehran University Heart Center (2016)
42. A Comparison of Fatty Acid Profiles in Highly Demanded Traditional and Fast Foods in Isfahan, Iran, Journal of Nutrition and Food Security (2022)
43. Potato Consumption and Cardiovascular Disease Risk Factors Among Iranian Population, International Journal of Food Sciences and Nutrition (2012)
44. The Association Between Poly Unsaturated Fatty Acids Intake, Body Mass Index and Waist Circumference Among Female Youths in Isfahan, Iran, Pakistan Journal of Medical Sciences (2013)
45. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
46. Effect of Potato Consumption As a High Glycemic Index Food on Pre-Diabetes Adult Patients, Pakistan Journal of Medical Sciences (2013)
47. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
48. Determinants of Incident Prediabetes and Type 2 Diabetes in a 7-Year Cohort in a Developing Country: The Isfahan Cohort Study, Journal of Diabetes (2015)
49. The Characteristics of Pre-Diabetic Patients Associated With Body Composition and Cardiovascular Disease Risk Factors in the Iranian Population, Journal of Research in Medical Sciences (2016)
50. Dietary Glycemic Index and Insulin Index in Association With Incident Type 2 Diabetes Mellitus in Adults, British Journal of Nutrition (2025)