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Nanosponges: An Overlooked Promising Strategy to Combat Sars-Cov-2 Publisher Pubmed



Mostafavi E1, 2 ; Iravani S3 ; Varma RS4
Authors
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Authors Affiliations
  1. 1. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, United States
  2. 2. Department of Medicine, Stanford University School of Medicine, Stanford, 94305, CA, United States
  3. 3. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Slechtitelu 27, Olomouc, 783 71, Czech Republic

Source: Drug Discovery Today Published:2022


Abstract

Among explored nanomaterials, nanosponge-based systems have exhibited inhibitory effects for the biological neutralization of, and antiviral delivery against, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More studies could pave the path for clarification of their biological neutralization mechanisms as well as the assessment of their long-term biocompatibility and biosafety issues before clinical translational studies. In this review, we discuss recent advances pertaining to antiviral delivery and inhibitory effects of nanosponges against SARS-CoV-2, focusing on important challenges and opportunities. Finally, as promising approaches for recapitulating the complex structure of different organs/tissues of the body, we discuss the use of 3D in vitro models to investigate the mechanism of SARS-CoV-2 infection and to find therapeutic targets to better manage and eradicate coronavirus 2019 (COVID-19). © 2022 Elsevier Ltd
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