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Association of Diabetes Risk Reduction Diet (Drrd) Score With Metabolic Health, Brain-Derived Neurotrophic Factor and Adropin in Iranian Adults Publisher Pubmed



Rashki A ; Moradmand Z ; Shahdadian F ; Rouhani P ; Saneei P
Authors

Source: Nutrition Journal Published:2025


Abstract

Background: The connection between the diabetes risk reduction diet (DRRD) score and metabolic health is not exactly clear. This study examined the association between DRRD score and metabolic health (MH), serum adropin, and brain-derived neurotrophic factor (BDNF) in Iranian adults. Methods: This cross-sectional investigation employed a sample of 527 adults (45.7% females) within the age range of 20 to 65 years, who were selected via a multistage cluster random sampling technique. Dietary assessment of participants was evaluated utilizing a validated food frequency questionnaire, while a fasting blood sample from each participant was procured to analyze biochemical parameters. MH status was ascertained according to the criteria delineated by Wildman et al. The DRRD score was calculated based on nine elements. Results: After adjusting for potential confounders, no significant association was observed between higher DRRD score tertiles and odds of metabolically unhealthy status (OR = 0.99; 95% CI: 0.58–1.70). Individuals in the highest tertile of DRRD score demonstrated a 44% (95% CI: 0.33–0.96) significant reduction in the odds of developing hypertriglyceridemia compared to those in the lowest tertile. However, no significant reduction was observed in other Metabolically Unhealthy (MU) components. Also, no significant difference was observed in BDNF and adropin levels among individuals in DRRD score tertiles. Conclusions: A Higher DRRD score was associated with reduced odds of hypertriglyceridemia, but no significant associations were observed with other metabolic unhealthy components or BDNF and adropin levels. © The Author(s) 2025.
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