Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Mediterranean Diet and Metabolic Health Status Among Adults Was Not Mediated Through Serum Adropin Levels Publisher Pubmed



Shafiei M1, 2 ; Poursalehi D1, 2 ; Mohammadi S3 ; Shahdadian F4 ; Hajhashemy Z1, 2 ; Rouhani P5 ; Mokhtari E6 ; Saneei P2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, PO Box 81745-151, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
  6. 6. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: BMC Public Health Published:2025


Abstract

Background: Prevalence of metabolic disorders has been increased in recent years around the world. The relationship between Mediterranean diet (MD) with metabolic health status and serum adropin levels has been less examined in Iranian adults. We investigated the association between MD compliance with metabolic health status and adropin hormone in Iranian adults. Methods: This observational study was conducted on 527 men and women. Food intakes were evaluated by a validated food frequency questionnaire. Blood pressure and anthropometric parameters were measured. Fasting blood samples were drawn to measure serum adropin concentrations, blood glucose, triglycerides, high-density lipoprotein cholesterol, high sensitive C-reactive protein and insulin. Metabolic unhealthy (MU) status was defined as having ≥ 2 cardio-metabolic risk factors. Results: After adjustments for potential confounders, subjects in highest versus lowest tertile of MD had 52% lower odds of MU status (OR = 0.48, 95%CI: 0.23–0.97). Stratified analysis revealed a significant association in normal-weight participants (OR = 0.12; 95%CI: 0.02–0.64), but not in those with overweight/obesity (OR = 0.66, 95%CI: 0.27–1.57). By excluding each component of MD, the association disappeared, except for three components (vegetables, nuts and grains). MD adherence was not significantly related to serum adropin levels in multivariable-adjusted model (unstandardized B= -0.19, 95%CI: -4.97, 4.59; P = 0.94). Serum adropin hormone levels were also not substantially different among metabolic healthy versus unhealthy subjects (P = 0.66). Conclusions: This cross-sectional study showed an inverse association between adherence to MD and odds of MU status, especially in subjects with normal-weight. Serum adropin concentrations were not associated with MD adherence or metabolic health status. © The Author(s) 2025.
Related Docs
View other Related Docs
1. Ultra-Processed Foods Intake in Relation to Metabolic Health Status, Serum Brain-Derived Neurotrophic Factor and Adropin Levels in Adults, Nutrition Journal (2024)
2. Association Between Dietary Magnesium Intake With Serum Brain-Derived Neurotrophic Factor (Bdnf) and Adropin Levels and Metabolic Health Status in Iranian Adults, Biological Trace Element Research (2024)
3. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
4. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
5. Adherence to Mediterranean Diet and Its Association With Metabolic Health Status in Overweight and Obese Adolescents, International Journal of Clinical Practice (2022)
6. Dietary Intake of Methyl Donor Nutrients in Relation to Metabolic Health Status, Serum Levels of Brain-Derived Neurotrophic Factor and Adropin, Clinical Nutrition (2024)
7. Association of Plant-Based Diets With Adropin, Atherogenic Index of Plasma, and Metabolic Syndrome and Its Components: A Cross-Sectional Study on Adults, Frontiers in Nutrition (2023)
8. Nutrient Patterns in Relation to Metabolic Health Status and Serum Levels of Brain-Derived Neurotrophic Factor (Bdnf) and Adropin in Adults, Scientific Reports (2024)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (100)
Roya Kelishadi (80)
Other Related Docs
9. Adherence to Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay Diet in Relation to Serum Brain-Derived Neurotrophic Factor Concentrations and Metabolic Health Status in Adults, Current Developments in Nutrition (2024)
10. Legumes and Nuts Intake in Relation to Metabolic Health Status, Serum Brain Derived Neurotrophic Factor and Adropin Levels in Adults, Scientific Reports (2023)
11. The Relationship Between Dietary Patterns and Metabolic Phenotypes: A Cross-Sectional Study in a Representative Sample of Iranian Industrial Employees, Metabolic Syndrome and Related Disorders (2024)
12. Longitudinal Association of Metabolic Syndrome and Dietary Patterns: A 13-Year Prospective Population-Based Cohort Study, Nutrition, Metabolism and Cardiovascular Diseases (2018)
13. Adherence to Lifelines Diet Score and Risk Factors of Metabolic Syndrome Among Overweight and Obese Adults: A Cross-Sectional Study, Frontiers in Nutrition (2022)
14. How Dietary Patterns Could Have a Role in Prevention, Progression, or Management of Diabetes Mellitus? Review on the Current Evidence, Journal of Research in Medical Sciences (2012)
15. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)
16. Adherence to Healthy Eating Index-2010 Is Inversely Associated With Metabolic Syndrome and Its Features Among Iranian Adult Women, European Journal of Clinical Nutrition (2017)
17. Association Between Plant-Based Diets and Metabolic Syndrome in Obese Adults From Iran: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
18. The Relationship Between the Mediterranean-Dash Intervention for Neurodegenerative Delay (Mind) Diet and Metabolic Health Status in Adolescents With Overweight and Obesity: Results From a Cross-Sectional Study in Iran, British Journal of Nutrition (2024)
19. Associations Between Empirically Derived Dietary Patterns and Cardiovascular Risk Factors Among Older Adult Men: A Cross-Sectional Study, International Journal for Vitamin and Nutrition Research (2023)
20. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
21. Adherence to Dietary Approaches to Stop Hypertension (Dash) and Mediterranean Dietary Patterns in Relation to Cardiovascular Risk Factors in Older Adults, Clinical Nutrition ESPEN (2020)
22. Are Women With Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?, Biomedicines (2023)
23. Associations Between Dietary Insulin Load With Cardiovascular Risk Factors and Inflammatory Parameters in Elderly Men: A Cross-Sectional Study, British Journal of Nutrition (2019)
24. Adherence to Mediterranean Dietary Pattern Is Inversely Associated With Depression, Anxiety and Psychological Distress, Nutritional Neuroscience (2021)
25. Ultra-Processed Food Intake in Relation to Metabolic Health Status in Iranian Adolescents With Overweight and Obesity, Nutrition and Metabolism (2024)
26. Relationship Between Major Dietary Patterns and Metabolic Syndrome Among Individuals With Impaired Glucose Tolerance, Nutrition (2010)
27. Association Between Mediterranean Dietary Pattern With Sleep Duration, Sleep Quality and Brain Derived Neurotrophic Factor (Bdnf) in Iranian Adults, Scientific Reports (2023)
28. Nutrient Patterns in Relation to Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2023)
29. The Relation Between Dietary Phytochemical Index and Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2023)
30. Identification of Diet-Disease Relations Through Dietary Pattern Approach: A Review, Journal of Research in Medical Sciences (2008)
31. Association Between Adherence to the Mediterranean Diet and Renal Function Biomarkers and Cardiovascular Risk Factors Among Diabetic Patients With Nephropathy, Clinical Nutrition ESPEN (2020)
32. Consumption of Sugar-Sweetened Beverages in Relation to the Metabolic Syndrome Among Iranian Adults, Obesity Facts (2012)
33. Dietary Patterns, Insulin Resistance, and Prevalence of the Metabolic Syndrome in Women, American Journal of Clinical Nutrition (2007)
34. Association of Adherence to the Dietary Approach to Stop Hypertension and Mediterranean Diets With Blood Pressure in a Non-Hypertensive Population: Results From Isfahan Salt Study (Iss), Nutrition, Metabolism and Cardiovascular Diseases (2022)
35. Association of the Elderly Dietary Index With Cardiovascular Disease Risk Factors in Elderly Men: A Cross-Sectional Study, Nutrition and Dietetics (2019)
36. Diet in Relation to Metabolic, Sleep and Psychological Health Status (Dimets): Protocol for a Cross-Sectional Study, BMJ Open (2023)
37. First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care (2009)
38. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)
39. Healthy Eating Index and Cardiovascular Risk Factors Among Iranians, Journal of the American College of Nutrition (2013)
40. Consumption of Energy-Dense Diets in Relation to Cardiometabolic Abnormalities Among Iranian Women, Public Health Nutrition (2012)
41. Elastic Band Resistance Training Increases Adropin and Ameliorates Some Cardiometabolic Risk Factors in Elderly Women: A Quasi-Experimental Study, BMC Sports Science, Medicine and Rehabilitation (2022)
42. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
43. Dietary Energy Density and the Metabolic Syndrome Among Iranian Women, European Journal of Clinical Nutrition (2011)
44. The Association Between Dietary Habits and Metabolic Syndrome: Findings From the Shahedieh-Cohort Study, BMC Nutrition (2022)
45. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
46. Association of Glycaemic Index and Glycaemic Load With Metabolic Syndrome in an Iranian Adult Population: Isfahan Healthy Heart Program, Nutrition and Dietetics (2017)
47. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
48. The Effect of a Moderately Restricted Carbohydrate Diet on Cardiometabolic Risk Factors in Overweight and Obese Women With Metabolic Syndrome: A Randomized Controlled Trial, Clinical Therapeutics (2023)
49. Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?, Cholesterol (2013)
50. The Mind (Mediterranean-Dash Diet Intervention for Neurodegenerative Delay) and Mediterranean Diets Are Differently Associated With Psychosomatic Complaints Profile in Adults: Results From Sepahan Cross-Sectional Study, Mediterranean Journal of Nutrition and Metabolism (2020)