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Multifocal Electroretinogram in Diabetic Macular Edema; Correlation With Visual Acuity and Optical Coherence Tomography Publisher



Tehrani NM1 ; Riaziesfahani H2 ; Jafarzadehpur E1 ; Mirzajani A1 ; Talebi H3 ; Amini A2 ; Mazloumi M2 ; Roohipoor R2 ; Riaziesfahani M2
Authors
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Authors Affiliations
  1. 1. Department of Optometry, Faculty of Rehabilitation, University of Medical Sciences, Tehran, Iran
  2. 2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Qazvin Square, Tehran, 13366, Iran
  3. 3. Department of Audiology, School of Rehabilitation Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Ophthalmic and Vision Research Published:2015


Abstract

Purpose: To evaluate multifocal electroretinogram (mfERG) changes in eyes with diabetic macular edema (DME) and investigate any possible correlation with optical coherence tomography (OCT) features and visual acuity (VA). Methods: Twenty-nine right eyes of 29 subjects with DME due to non-proliferative diabetic retinopathy and 30 eyes of 30 normal subjects were evaluated. All patients underwent a complete ophthalmic examination. Sixty-one scaled hexagon mfERG responses were recorded. Components of thefirst order kernel of N1, N2, and P1 in five concentric rings centered on the fovea, were measured in both groups. Correlation and regression analyses were performed among VA, central macular thickness (CMT) based on OCT, mfERG amplitude, and latency of the N1, N2 and P1 waves. Results: Significant differences were observed in all mfERG parameters in five-ring regions of the retina between eyes with DME versus controls (P < 0.05). There were significant correlations among VA with N2 (P = 0,001, b = 0.73) and P1 amplitudes (P = 0.001, b = -0.84) in the central macular area, and there was a borderline association between VA and CMT (P = 0.042, b = 0.392). Conclusion: Amplitudes of mfERG components (N1, P1, and N2) are significantly reduced and their latencies are delayed in eyes with DME indicating functional impairment in the outer retina. The mfERG total amplitude was significantly correlated with VA even more than CMT, therefore the combined use of OCT and mfERG for macular evaluation may better evaluate visual status in DME patients. © 2015 Journal of Ophthalmic and Vision Research.
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