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Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer Publisher Pubmed

Summary: Research suggests targeted nanoparticles enhance cancer drug delivery, improving breast cancer treatment. #CancerResearch #BreastCancer

Ramezanialiakbari M1, 2 ; Varshosaz J1 ; Mirian M1 ; Khodarahmi G1 ; Rostami M1
Authors

Source: Journal of Microencapsulation Published:2022


Abstract

Aim: This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type manganese polyoxomolybdate (POMo) to breast cancer. Methods: The POMo@SBA-PDA-Glu NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterisation methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit. Results: The optimised NPs had a hydrodynamic size (HS) of 195 nm, a zeta potential (ZP) of −18.9 mV, a loading content percent (LC%) of 45%, and a pH-responsive release profile. The targeted NPs showed increased anticancer activity against breast cancer cell lines compared to the free POMo with the highest cellular uptake and apoptosis level in the MDA-MB-231 cells. Conclusions: POMo@SBA-PDA-Glu NPs could be a promising anticancer candidate for further studies. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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