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Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells Publisher



Mohajer S1 ; Varshosaz J2 ; Jahaniannajafabadi A3 ; Sadri F2 ; Sadeghi F1 ; Rafiemanzelat F4 ; Rostami M5
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Polymer Technology Research Group, University of Isfahan, Isfahan, Iran
  5. 5. Novel Drug Delivery Systems Research Center, Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Inorganic and Organometallic Polymers and Materials Published:2024


Abstract

Novel nano-composites (NCs) of polyarsenotungstate (As2W19O67, POM) in bis-imidazolium based poly ionic liquid (PolyIL) were developed for co-delivery of curcumin (CUR) and POM to triple-negative breast cancer cell line (MDA-MB-231) for the first time. The anticancer activity of optimized NCs was evaluated against MDA-MB-231 cancer cells and HUVEC normal cells using the MTT assay. Cellular uptake was also evaluated on the MDA-MB-231 cell line. The optimized NCs had a particle size around 200 nm and a zeta potential of about + 22.4 mV. PolyIL NCs showed a pH-responsive independent drug release profile for CUR and POM. NCs had better anticancer activity (IC50: 40.49 µg/mL) than free POM (IC50: 95.35 µg/mL) without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100% after 4 h. The CUR-POM@PolyIL NCs could surprisingly modulate the cytotoxicity of arsenotungstate polyoxometalate. These results are convincing enough to warrant further pre-clinical studies. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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