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The Effect of Astaxanthin Supplementation on Inflammatory Markers, Oxidative Stress Indices, Lipid Profile, Uric Acid Level, Blood Pressure, Endothelial Function, Quality of Life, and Disease Symptoms in Heart Failure Subjects Publisher Pubmed



Mohammadi SG1 ; Feizi A3 ; Bagherniya M4 ; Shafie D5 ; Ahmadi AR6 ; Kafeshani M7
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition & amp
  2. 2. Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Epidemiology and Biostatistics Department, Health School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biomedical Sciences, Women Research Center, Alzahra University, Tehran, Iran
  7. 7. Nutrition and Food Security Research Centerand, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Trials Published:2024


Abstract

Background: Heart failure is a chronic and progressive disease where the heart muscle is unable to pump enough blood and oxygen to meet the body’s needs. Oxidative stress and inflammation are key elements in the development and progression of heart failure. Astaxanthin, a carotenoid, has strong anti-inflammatory and antioxidant effects that may protect the cardiovascular system. A study will evaluate the effect of astaxanthin supplementation on inflammatory status, oxidative stress, lipid profile, uric acid levels, endothelial function, quality of life, and disease symptoms in people with heart failure. Methods: The current study is a double-blind controlled randomized clinical trial for 8 weeks, in which people with heart failure were randomly assigned to two groups: intervention (one capsule containing 20 mg of astaxanthin per day, n = 40) and placebo (one capsule containing 20 mg of maltodextrin per day, n = 40) will be divided. At the beginning and end of the intervention, uric acid, lipid profile, oxidative stress indices, inflammatory markers, blood pressure, nitric oxide, and anthropometric factors will be measured, and questionnaires measuring quality of life, fatigue intensity, shortness of breath, and appetite will be completed. SPSS version 22 software will be used for statistical analysis. Discussion: There is a growing global interest in natural and functional food products. This RCT contributes to the expanding body of research on the potential benefits of astaxanthin in heart failure patients, including its antioxidant, lipid-lowering, and anti-inflammatory effects. Trial registration: Iranian Registry of Clinical Trials IRCT20200429047235N3. Registered on 26 March 2024. © The Author(s) 2024.
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