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Selenium Supplementation and Oxidative Stress: A Review Publisher



Zakeri N1 ; Kelishadi MR2 ; Asbaghi O3 ; Naeini F4 ; Afsharfar M5 ; Mirzadeh E6 ; Naserizadeh SK7
Authors
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Authors Affiliations
  1. 1. Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Department of Clinical Nutrition, School of Nutritional Science, Tehran University of Medical Science, Tehran, Iran
  5. 5. Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  6. 6. Department of Phisycal Ejucation And Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  7. 7. Tehran University of Medical Sciences, Tehran, Iran

Source: PharmaNutrition Published:2021


Abstract

Background: Oxidative stress is defined as an imbalance between the production of oxidants (free radicals or reactive oxygen species) and their eradication by protective mechanisms, such as antioxidants (vitamin C, vitamin E, b-carotene, selenium and methionine). Increased oxidative stress is associated with metabolic risk factors and may contribute to the development of several obesity-related comorbidities, including insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis. Methods: The present review aimed to evaluate the effects of selenium supplementation on oxidative stress biomarkers. We have searched PubMed, Scopus, ISI web of science, Embase and the Cochrane library databases were searched to evaluate the clinical efficacy. Results: We detected 14 studies that evaluated the effect of selenium supplementation on oxidative stress biomarkers n adults. Conclusions: Several studies have shown that Supplementation with selenium significantly reduce Malondialdehyde levels and increase Glutathione and total antioxidant capacity levels. © 2021
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