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The Antioxidant and Anti-Inflammatory Effects of Astaxanthin Supplementation on the Expression Of Mir-146A and Mir-126 in Patients With Type 2 Diabetes Mellitus: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Shokrimashhadi N1, 2 ; Tahmasebi M3, 4 ; Mohammadiasl J5 ; Zakerkish M6 ; Mohammadshahi M2
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Authors Affiliations
  1. 1. Department of Clinical Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nutrition and Metabolic Diseases Research Center and Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Iran
  5. 5. Deptment of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Endocrinology and Metabolism, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: International Journal of Clinical Practice Published:2021


Abstract

Background: The pathogenesis of type 2 diabetes mellitus (T2DM) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA-146a is upregulated in diabetic and hyperglycaemic patients, whereas circulating miRNA-126 is reduced. Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM. Methods: This randomised, double-blind, placebo-controlled clinical trial was conducted in 44 patients with T2DM randomly receiving 8 mg/d of oral AST (n = 22) or placebo (n = 22) for 8 weeks. Results: We observed that AST supplementation could decrease plasma levels of MDA and IL-6 (P <.05) and decrease the expression level of miR-146a over time (fold change: −1/388) (P <.05). Conclusion: AST supplementation might be beneficial for improving circulating MDA and IL-6 and the down-regulation of miR-146a. However, future investigations are suggested to confirm these results. © 2021 John Wiley & Sons Ltd
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