Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Obstructive Sleep Apnea, Diagnosed by the Berlin Questionnaire and Association With Coronary Artery Disease Severity



Ghazal A1 ; Roghani F1 ; Sadeghi M2 ; Amra B3 ; Kermanialghoraishi M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pulmonology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2015

Abstract

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep-related disorder that is associated with increased risk of hypertension (HTN) and coronary heart disease. This study aimed to evaluate the correlation between the OSAS and coronary artery disease (CAD) severity. METHODS: The cross-sectional study was conducted from September 2012 to December 2013. We enrolled 127 patients with chronic stable angina who were referred for coronary angiographic studies in Shahid Chamran and Nour Hospitals in Isfahan, Iran. The Berlin questionnaire (BQ) was used for estimate the probability of OSAS in patients as a low or high probability. Demographic characteristics and metabolic risk factors including diabetes mellitus, HTN, obesity, and smoking also were recorded. The severity of CAD was assessed and compared based on the Gensini score with Mann–Whitney U statistical test. Independent t-test for continuous variables and chi-square test for categorical variables were used. RESULTS: Totally, 65.4% of subjects were considered as high and 34.6% as low probability for OSAS, which 81.1% of them had CAD. There was a significant difference between body mass index, systolic blood pressure, diastolic blood pressure, and ischemic heart disease drug consumption with OSAS probability (P < 0.0500). CAD was accompanied by OSAS significantly (P = 0.0260). The Gensini score was significantly higher in patients with high OSAS probability (100.4 ± 69.1 vs. 65.3 ± 68.9; P = 0.0030). OSAS also increase odds of CAD based on regression analysis (odds ratio, 95% confidence interval = 2.7). CONCLUSION: This study indicates that more severe CAD is associated with high OSAS probability identified by BQ. © 2015 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Screening Questionnaires for Obstructive Sleep Apnea: An Updated Systematic Review, Oman Medical Journal (2018)
2. Validation of the Persian Version of Berlin Sleep Questionnaire for Diagnosing Obstructive Sleep Apnea, International Journal of Preventive Medicine (2013)
3. Effect of Cpap Therapy on Serum Lipids and Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome, Tanaffos (2019)
4. Hypoxic Burden to Guide Cpap Treatment Allocation in Patients With Obstructive Sleep Apnoea: A Post Hoc Study of the Isaacc Trial, European Respiratory Journal (2023)
5. Clinical and Polysomnographic Characteristics of Patients With Extreme Obstructive Sleep Apnea, Ahi > 100: A Case-Control Study, Shiraz E Medical Journal (2021)
6. P Wave Duration and Dispersion in Holter Electrocardiography of Patients With Obstructive Sleep Apnea, Sleep and Breathing (2014)
7. Determination of the Incidence of Cardiovascular Composite Events in Patients With Obstructive Sleep Apnea: A 3-Year Follow-Up Study, ARYA Atherosclerosis (2023)
8. Prevalence of Sleep Apnea-Related Symptoms in a Persian Population, Sleep and Breathing (2011)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (27)
Babak Amra (26)
Other Related Docs
9. Obstructive Sleep Apnea and Postoperative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Need for Preventive Strategies, International Journal of Preventive Medicine (2014)
10. Comparison of Berlin Questionnaire, Stop-Bang, and Epworth Sleepiness Scale for Diagnosing Obstructive Sleep Apnea in Persian Patients, International Journal of Preventive Medicine (2018)
11. Relationship Between Obstructive Sleep Apnea and 30-Day Mortality Among Patients With Pulmonary Embolism, Journal of Research in Medical Sciences (2015)
12. Evaluation of Plasma/Serum Adiponectin (An Anti-Inflammatory Factor) Levels in Adult Patients With Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis, Life (2022)
13. Investigation of Symptoms and Risk Factors of Obstructive Sleep Apnea Among Patients With Acute Stroke Who Were Hospitalized in Alzahra Hospital, Isfahan, Iran, During 2014, Journal of Isfahan Medical School (2016)
14. The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients With Obstructive Sleep Apnea Syndrome: A Case-Control Study, International Journal of Preventive Medicine (2022)
15. Which Majot Atherosclerosis’ Risk Factors Represents the Extent of Coronary Artery Disease?, Journal of Isfahan Medical School (2007)
16. Sleep Apnea Symptoms in Diabetics and Their First Degree Relatives, International Journal of Preventive Medicine (2012)
17. Association Between Sleep Duration and Hypertension: Isfahan Healthy Heart Program, Iran, ARYA Atherosclerosis (2019)
18. Association Between Sleep Duration and Metabolic Syndrome in a Population-Based Study: Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2011)
19. A Cross- Sectional Study on the Association Between Lifestyle Factors and Coronary Artery Stenosis Severity Among Adults Living in Central Iran: A Protocol for the Iranian- Cardio Study, ARYA Atherosclerosis (2024)
20. Predictors of Health-Related Quality of Life Among Iranian People With Type 2 Diabetes, Journal of Nephropharmacology (2023)
21. The Prevalence of Coronary Artery Disease in an Urban Population in Isfahan, Iran, Acta Cardiologica (1999)
22. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
23. Healthcare Workers’ Sleep and Mood Disturbances During Covid-19 Outbreak in an Iranian Referral Center, Sleep and Breathing (2021)
24. Assessment of Metabolic Risk Factors and Heart-Healthy Lifestyle in Atherosclerotic Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention After a 6-Month Follow-Up, Advanced Biomedical Research (2022)
25. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
26. Association Between Sleep Duration and Diabetes Mellitus: Isfahan Healthy Heart Program, Nigerian Journal of Clinical Practice (2013)
27. Factor Analysis of Cardiovascular Risk Clustering in Pediatric Metabolic Syndrome: Caspian Study, Annals of Nutrition and Metabolism (2007)
28. Relationship Between Pulmonary Artery Diameter and Pulmonary to Aortic Artery Diameter Ratio in High Risk Individuals for Obstructive Sleep Apnea Without Pulmonary Artery Hypertension Based on the Berlin Questionnaire, Tanaffos (2020)
29. Nocturnal Heart Rate Variation in Diabetic and Non-Diabetic Patients With Sleep Apnea Syndrome, Sleep Medicine (2017)
30. The Impact of Obesity on Hypertension and Diabetes Control Following Healthy Lifestyle Intervention Program in a Developing Country Setting, Journal of Research in Medical Sciences (2011)
31. Is Prehypertension a Risk Factors for Cardiovascular Diseases Among Iranian Women?, Journal of Research in Medical Sciences (2012)
32. Effect of Continuous Positive Airway Pressure Therapy on Blood Levels of Il-6, Il-10, Il-18, Il-1Β, Il-4, and Il-17 in Obstructive Sleep Apnoea Adults: A Systematic Review, Meta-Analysis and Trial Sequential Analysis, International Orthodontics (2024)
33. Comparison of Epicardial Fat Thickness in Patients With Acute Coronary Syndrome or Chronic Stable Angina and Normal Individuals, Journal of Isfahan Medical School (2012)
34. Atherosclerosis and Multiple Sclerosis: An Overview on the Prevalence of Risk Factors, Multiple Sclerosis and Related Disorders (2022)
35. Age at Menarche and Risk of Premature Coronary Artery Disease: Results From Iran Premature Coronary Disease (Ipad) Study, Archives of Gynecology and Obstetrics (2025)
36. Ethnic Differences in the Lifestyle Behaviors and Premature Coronary Artery Disease: A Multi-Center Study, BMC Cardiovascular Disorders (2023)
37. Timing and Length of Nocturnal Sleep and Daytime Napping and Associations With Obesity Types in High-, Middle-, and Low-Income Countries, JAMA Network Open (2021)
38. The Association Between Sleep Quality, Health Status and Disability Due to Breathlessness in Chronic Obstructive Pulmonary Disease Patients, Clinical Respiratory Journal (2021)
39. Current Status of the Clinical Epidemiology of Myocardial Infarction in Men and Women: A National Cross-Sectional Study in Iran, International Journal of Preventive Medicine (2015)
40. The Association of Leisure Time Physical Activity, Watching Television, Obesity & Lipid Profile in an Iranian Population, Pakistan Journal of Medical Sciences (2005)
41. Correlation Between Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Syndrome in a General Population in Iran, Journal of Research in Medical Sciences (2011)
42. Cardiovascular Disease Risk Assessment: Triglyceride/High-Density Lipoprotein Versus Metabolic Syndrome Criteria, Journal of Research in Health Sciences (2019)
43. Metabolic Syndrome Components and Long-Term Incidence of Cardiovascular Disease in Eastern Mediterranean Region: A 13-Year Population-Based Cohort Study, Metabolic Syndrome and Related Disorders (2019)
44. Heart Rate and Cardiovascular Events: A Nested Case-Control in Isfahan Cohort Study, Archives of Iranian Medicine (2014)
45. The Association Between Daytime Sleep and General Obesity Risk Differs by Sleep Duration in Iranian Adults, Annals of Human Biology (2023)
46. Analysis of Traditional Risk Factors on St-Segment Elevation Myocardial Infarction Characteristics; [بررسی عوامل خطر سنتی مرتبط با ویژگیهای بالینی بیماران انفارکتوس میوکارد با بالارونده قطعه St], Journal of Isfahan Medical School (2024)
47. Relationship Between Metabolic Syndrome and Angiographic Severity of Coronary Artery Disease, ARYA Atherosclerosis (2016)
48. Evaluation and Comparison of Knowledge, Attitude, and Practice of Sleep Hygiene in Students of Different Universities of Isfahan City, Iran, Journal of Isfahan Medical School (2019)
49. Evaluation of the Coronary Angiography Results in Patients Referred to Cardiac Centers in Isfahan City, Iran, Journal of Isfahan Medical School (2017)
50. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)