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Dietary Polyphenols and the Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis Publisher Pubmed



Ramaiah P1 ; Baljon KJ1 ; Hjazi A2 ; Qasim MT3 ; Salih Alani OA4 ; Imad S5 ; Hussien BM6 ; Alsalamy A7 ; Garousi N8
Authors
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Authors Affiliations
  1. 1. Faculty of Nursing, Umm al- Qura University, Makkah, Saudi Arabia
  2. 2. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  3. 3. Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq
  4. 4. Department of Pharmacy, Al Rafidain University College, Bagdad, Iraq
  5. 5. Medical Technical College, Al-Farahidi University, Baghdad, Iraq
  6. 6. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  7. 7. College of medical technology, Imam Ja’afar Al-Sadiq University, Al‐Muthanna, 66002, Iraq
  8. 8. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: BMC Endocrine Disorders Published:2024


Abstract

Background: Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS. Methods: The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model. Results: A total of 14 studies (6 cohort and 8 cross-sectional studies) involving a total of 50,366 participants with 10,879 cases of MetS were included. When various polyphenol compounds were pooled, they were significantly related to a 22% decreased odds of MetS (([5 studies]; OR: 0.78; 95%CI: 0.72–0.85). Higher intakes of total flavonoids (([9 studies]; OR: 0.78; 95%CI: 0.72–0.85), flavan-3-ols (([2 studies]; OR: 0.64; 95%CI: 0.43–0.94), isoflavones (([3 studies]; OR: 0.84; 95%CI: 0.75–0.93), stilbenes (([4 studies]; OR: 0.86; 95%CI: 0.76–0.97), flavones (([2 studies]; OR: 0.79; 95%CI: 0.71–0.89), and quercetin (([2 studies]; OR: 0.63; 95%CI: 0.43–0.93) were also significantly associated with a decreased risk of MetS. The associations were not modified by the age of the participants. No association was found for total polyphenols, phenolic acids, lignans, anthocyanins, and flavonols. Conclusion: The results of this meta-analysis supported that higher polyphenol intake can lower the risk of MetS. © The Author(s) 2024.
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