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Comparing the Association of Novel Anthropometric and Atherogenicity Indices With All-Cause, Cardiovascular and Non-Cardiovascular Mortality in a General Population of Iranian Adults Publisher



Hajihashemi P1 ; Mohammadifard N2 ; Bateni M2 ; Haghighatdoost F3 ; Boshtam M3 ; Najafian J4 ; Sadeghi M5 ; Shabani N3 ; Sarrafzadegan N3
Authors
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Authors Affiliations
  1. 1. Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: American Journal of Preventive Cardiology Published:2025


Abstract

Background: The association of novel anthropometrics and novel atherogenicity indices with mortality remains uncertain. Objective: To compare the association of novel anthropometrics and atherogenicity indices with all-cause, cardiovascular (CVD), and non-CVD mortality in Iranian adults. Methods: Utilizing data from Isfahan Cohort Study, 5432 participants aged older than 35 years were enrolled. Three anthropometrics indices including a body shape index (ABSI), body roundness index (BRI) and abdominal volume index (AVI), and three atherogenicity indices including atherogenic index of plasma (AIP), Castelli risk index (CRI) and the cholesterol index (CI) were calculated. Cox proportional hazards regression models were used to explore the association between indices and mortality. Results: After a median follow-up of 11.25 years, the ABSI was independently associated with increased risk of all-cause mortality (HRQ4 vs. Q1 = 1.43, 95 % CI: 1.07, 1.92; P trend = 0.02). A positive, independent association was also observed between CRI-II (HRQ4 vs. Q1 = 1.49, 95 % CI: 0.99, 2.25; P trend = 0.04) and AIP (HRQ4 vs. Q1 = 1.81, 95 % CI: 1.92, 2.27; P trend = 0.01) and CVD mortality. For non-CVD mortality, despite a direct link for ABSI (HRQ4 vs. Q1 = 1.92, 95 % CI: 1.32, 2.80; P trend = 0.001), an inverse association was found for CI (HRQ4 vs. Q1 = 0.68, 95 % CI: 0.49, 0.95; P trend = 0.007). Conclusion: Amongst various investigated anthropometric indices, ABSI was directly related to all-cause and non-CVD mortality. However, atherogenicity indices including CRI-II and AIP could predict the incidence risk of CVD mortality among Iranians. Further studies are warranted to confirm these findings. © 2025 The Author(s)
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