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Mechanisms of Chemoresistance in Tumor-Derived Cancer Stem Cells



Mirzaei HR1, 2, 3 ; Gharagozloo M2 ; Rezaei A2 ; Soleimani M1, 3 ; Kalantari H4 ; Mirzaei H5 ; Eghbali M6 ; Chamanara M6 ; Tajadini M7
Authors
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Authors Affiliations
  1. 1. Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biotechnology, School of Basic Sciences, Karaj Payam Noor University, Karaj, Iran
  6. 6. Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

The existence of cancer stem cells (CSCs) has been already established in several hematopoietic and non-hematopoietic cancers. Chemoresistance has also been demonstrated as a major cause of cancer treatment failure. Although chemotherapy kills most cells in a tumor, it is believed to leave CSCs behind which might be an important mechanism of resistance and thereby cancer treatment failure. The quiescent nature and existence of adenosine triphosphate (ATP)-binding cassette (ABC) drug transporters in CSCs have been suggested to protect them from chemotherapeutic agents. Gaining a better insight into the mechanisms of CSCs chemoresistance might therefore lead to new therapeutic targets and development of better anticancer strategies.
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