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Programmed Cell Death and Melatonin: A Comprehensive Review Publisher Pubmed



Rafiyian M1, 2 ; Reiter RJ3 ; Rasooli Manesh SM4 ; Asemi R5 ; Sharifi M5 ; Mohammadi S6 ; Mansournia MA7 ; Asemi Z2
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Authors Affiliations
  1. 1. Student Research Committee, Kashan University of Reiter Sciences, Kashan, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Cell Systems and Anatomy, UT Health. Long School of Medicine, San Antonio, TX, United States
  4. 4. Department of Internal Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Functional and Integrative Genomics Published:2024


Abstract

Melatonin (MLT), a main product of pineal gland, recently has attracted the attention of scientists due to its benefits in various diseases and also regulation of cellular homeostasis. Its receptor scares widely distributed indicating that it influences numerous organs. Programmed cell death (PCD), of which there several types, is a regulated by highly conserved mechanisms and important for development and function of different organs. Enhancement or inhibition of PCDs could be a useful technique for treatment of different diseases and MLT, due to its direct effects on these pathways, is a good candidate for this strategy. Many studies investigated the role of MLT on PCDs in different diseases and in this review, we summarized some of the most significant studies in this field to provide a better insight into the mechanisms of modulation of PCD by MLT modulation. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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