Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of the Effects of Preemptive Intravenous and Rectal Acetaminophen on Pain Management After Inguinal Herniorrhaphy in Children: A Placebo-Controlled Study Pubmed



Khalili GR1 ; Shafa A1 ; Yousefi R2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Anesthesia and intensive care research center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran

Source: Middle East Journal of Anesthesiology Published:2016


Abstract

Background: Postoperative pain management is a critical concern in pediatric surgery. Acetaminophen is the safest and most widely used analgesic in children. The present study compared the analgesic efficacy of intravenous (IV) and rectal acetaminophen versus placebo in children undergoing inguinal herniorrhaphy. Methods: A total of 120 children, who were candidate for elective surgical repair of unilateral inguinal hernia, were enrolled and randomly allocated to four groups of 30 patients each to receive IV acetaminophen, acetaminophen suppository, IV placebo, and placebo suppository during surgery. Postoperative pain scores, measured on the Face, Legs, Activity, Cry, and Consolability (FLACC) scale, were recorded and compared. Results: The four groups had no significant differences in the mean age, weight, length of stay in the recovery room, and duration of operation. The frequency of postoperative vomiting was significantly lower in the IV and rectal acetaminophen groups compared to the two placebo groups (P = 0.04). The mean pain scores of the two acetaminophen groups were similar during the first two hours after surgery. These scores were significantly lower than the scores of the placebo groups. However, the four groups were not significantly different in terms of pain scores at the fourth, sixth, and 12th postoperative hours. During the first hour after surgery, IV acetaminophen had the largest analgesic effect. Moreover, among all four groups, the IV acetaminophen group had the highest sedation level in the recovery room. Conclusion: Both IV and rectal acetaminophen were more effective than placebo in pain relief after inguinal hernia repair in children. They were also associated with lower frequencies of postoperative vomiting. The greatest analgesic efficacy of both forms was observed during the first two hours after surgery. © 2016, American University of Beirut. All rights reserved.
Related Docs
View other Related Docs
1. Preemptive Analgesia With Ibuprofen and Acetaminophen in Pediatric Lower Abdominal Surgery, Journal of Research in Medical Sciences (2005)
2. Comparison of the Preventive Analgesic Effect of Rectal Ketamine and Rectal Acetaminophen After Pediatric Tonsillectomy, International Journal of Preventive Medicine (2012)
3. A Comparative Study of the Analgesic Effects of Pethidine Versus Ketorolac and Acetaminophen After Lower Abdominal and Genital Surgeries in Children, Journal of Isfahan Medical School (2017)
4. The Effect of Subcutaneous Injection of Metoclopramide, Pethidine, and Ketamine on Postoperative Pain After Inguinal Hernia Repair Under General Anesthesia, Journal of Isfahan Medical School (2020)
5. A Comparative Study of the Analgesic Effect of Intravenous Pethidine Vs. Ketorolac After Inguinal Hernia Surgery in Children Under General Anesthesia, Middle East Journal of Anesthesiology (2016)
6. Prophylactic Use of Oral Acetaminophen or Iv Dexamethasone and Combination of Them on Prevention Emergence Agitation in Pediatric After Adenotonsillectomy, International Journal of Preventive Medicine (2014)
7. Comparison of Pre- Vs. Post-Incisional Caudal Bupivacaine for Postoperative Analgesia in Unilateral Pediatric Herniorrhaphy: A Double-Blind Randomized Clinical Trial, Saudi Journal of Anaesthesia (2011)
8. Effect of Preemptive and Preventive Acetaminophen on Postoperative Pain Score: A Randomized, Double-Blind Trial of Patients Undergoing Lower Extremity Surgery, Journal of Clinical Anesthesia (2013)
Experts (# of related papers)
View all Related Experts
Amir Shafa (22)
Saied Morteza Heidari (15)
Other Related Docs
9. Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery, Journal of Isfahan Medical School (2017)
10. Evaluation of Preventive Effectiveness of Intravenous Paracetamol in Post Partum Pain of Elective Cesarean Delivery With Spinal Anesthesia, Journal of Isfahan Medical School (2014)
11. Effect of Pre Vs. Post Incision Inguinal Field Block on Postoperative Pain After Pediatric Herniorrhapy, a Different Approach, Journal of Research in Medical Sciences (2007)
12. Comparing the Effect of Preemptive Intravenous Acetaminophen and Ketamine on Postoperative Pain, Journal of Isfahan Medical School (2015)
13. Comparison of the Effect of Combination of Dexamethasone, Ketamine, and Fentanyl With Combination of Metoclopramide, Ketamine, and Fentanyl on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy, Journal of Isfahan Medical School (2018)
14. Influence of Pre-Emptive Versus Preventive Analgesia With Oral Acetaminophen on Postoperative Pain in Painful Ophthalmic Surgeries: Which One Is Better?, Journal of Research in Medical Sciences (2007)
15. Effects of Acetaminophen and Ibuprofen on Pulpal Anaesthesia Immediately After Pulpectomy of Primary Maxillary Molars, Iranian Endodontic Journal (2019)
16. Assessment of the Effect of Local Versus General Anesthesia on the Pain Perception After Inguinal Hernia Surgery, Ambulatory Surgery (2013)
17. Efficacy of Pre-Incisional Subcutaneous Infiltration of Low-Dose Ketamine on Postoperative Pain After Cesarean Section, Pakistan Journal of Medical Sciences (2011)
18. The Preventative Analgesic Effect of Preincisional Peritonsillar Infiltration of Two Low Doses of Ketamine for Postoperative Pain Relief in Children Following Adenotonsillectomy. a Randomized, Double-Blind, Placebo-Controlled Study, Paediatric Anaesthesia (2008)
19. Effect of Oral Ketamine on the Postoperative Pain and Analgesic Requirement Following Orthopedic Surgery, Acta Anaesthesiologica Taiwanica (2006)
20. Comparative Controlled Study of Preventive Effect of Combinations of Ketamine and Metoclopramide Vs Ketamine and Paracetamol on Postoperative Pain, Journal of Isfahan Medical School (2018)
21. Comparison the Efficacy of Pre-Emptive Oral Celecoxib With Acetaminophen in Controlling Post-Operative Pain and Nausea After Lower Limb Surgery Under General Anesthesia, Journal of Cellular and Molecular Anesthesia (2016)
22. Midazolam Versus Ketamine in the Management of Emergence Agitation in Children Undergoing Lower Abdominal and Limb Surgeries, Tehran University Medical Journal (2012)
23. Effect of Different Doses of Paracetamol on Postoperative Pain After Gynecologic Laparoscopy, International Journal of Women's Health and Reproduction Sciences (2018)
24. Comparing the Effects of Ketamine Alone and in Combination With Metoclopramide on Postoperative Pain, Journal of Isfahan Medical School (2013)
25. Effect of Intravenous Infusion of Lidocaine on Pain Reduction After Cesarean Section Under General Anesthesia, Journal of Cellular and Molecular Anesthesia (2018)
26. A Randomized Evaluation of Intravenous Dexamethasone Versus Oral Acetaminophen Codeine in Pediatric Adenotonsillectomy: Emergence Agitation and Analgesia, Middle East Journal of Anesthesiology (2012)
27. Comparative Study of Preemptive Ketorolac and Tetracaine Eye Drops on the Need for Sedatives and Analgesics During and After Cataract Surgery, Koomesh (2022)
28. Comparison of Pre-Emptive Effect of Meloxicam and Celecoxcib on Post-Operative Analgesia: A Double-Blind, Randomized Clinical Trial, Middle East Journal of Anesthesiology (2015)
29. The Effect of Premediction Oral Naproxen on Post Operative Pain in Diagnostic Laparoscopy, Journal of Medical Sciences (2009)
30. Effect of High-Dose Intravenous Dexamethasone on Postlumbar Discectomy Pain, Spine (2006)
31. Comparison of the Effects of 3 Methods of Intrathecal Bupivacaine, Bupivacaine-Fentanyl, and Bupivacaine-Fentanyl-Magnesium Sulfate on Sensory Motor Blocks and Postoperative Pain in Patients Undergoing Lumbar Disk Herniation Surgery, Journal of Neurosurgical Anesthesiology (2016)
32. Premedication Propofol Dose to Prevent Emergency Delirium, Iranian Journal of Psychiatry (2022)
33. Effects of Lidocaine on Reducing the Need for Anesthetic Drugs During Ophthalmologic Surgeries, Journal of Isfahan Medical School (2013)
34. Comparison of Oral Melatonin and Midazolam As Premedication in Children Undergoing General Anesthesia for Dental Treatment, Anesthesiology and Pain Medicine (2018)
35. The Comparison of Spinal Anesthesia With General Anesthesia on the Postoperative Pain Scores and Analgesic Requirements After Elective Lower Abdominal Surgery: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
36. Comparison Between the Effect of Bupivacaine-Pethidine and Bupivacaine-Ketamine As Preemptive in Bilateral Infraorbital Nerve Block on Postoperative Pain Relief in Infants Undergoing Clef Lip Repair, a Controlled Study, Journal of Isfahan Medical School (2017)
37. Citalopram for Pediatric Functional Abdominal Pain: A Randomized, Placebo-Controlled Trial, Neurogastroenterology and Motility (2014)
38. Oral Midazolam Alone or in Combination With Ketamine As Oral Premedication in Pediatric Ophthalmologic Surgeries, Journal of Isfahan Medical School (2014)
39. The Effects of Intraarticular Opioids in Pain Relief After Arthroscopic Menisectomy: A Randomized Clinical Trial Study, Pakistan Journal of Medical Sciences (2012)
40. The Effect of Internal Mesh Fixation and External Fixation (Inguinal Hernia Truss) on Postoperative Complications in Patients With Inguinal Hernia Undergoing Totally Extraperitoneal Laparoscopic Hernioplasty, Advanced Biomedical Research (2022)
41. Comparing the Effectiveness of Intrathecal Injection of Marcaine With Magnesium Sulfate, Neostigmine or Phentanyl on Post-Operative Pain, Urinary Retention, Nausea or Vomiting in Patients Undergoing Spinal Anesthesia for Lumbar Disk Herniation Surgery, Journal of Isfahan Medical School (2016)
42. Comparison of the Preventive Effect of Ketamine, Paracetamol and Metoclopramide on Postoperative Pain Intensity in General Anesthesia: A Double-Blind Clinical Trial, Scientific Journal of Kurdistan University of Medical Sciences (2019)
43. Topical Lidocaine Plus Diclofenac As a Local Anesthetic Agent in Central Venous Catheterization; a Randomized Controlled Clinical Trial, Archives of Academic Emergency Medicine (2021)
44. Comparison of Intravenous and Epidural Patient-Controlled Analgesia After Knee and Hip Arthroplasty, Journal of Isfahan Medical School (2012)
45. Intranasal Ketamine Versus Intranasal Fentanyl on Pain Management in Isolated Traumatic Patients, Journal of Research in Medical Sciences (2022)
46. Efficacy of Fentanyl on Pain Relief During Tracheal Suctioning in Ventilated Children: A Randomized Clinical Trial, Trends in Anaesthesia and Critical Care (2022)
47. Preincisional Analgesia With Subcutaneous Administration of Tramadol Reduces Postoperative Pain in Patients After Open Urologic Surgeries: A Randomized, Double-Blind, Placebo-Controlled Study, Pakistan Journal of Medical Sciences (2012)
48. Mesh Fixation in Tapp Laparoscopic Hernia Repair: Introduction of a New Method in a Prospective Randomized Trial, Surgical Endoscopy (2014)
49. Investigating the Effect of Melissa Officinalis on After-Pains: A Randomized Single-Blind Clinical Trial, Journal of Caring Sciences (2019)
50. A Comparison of the Effects of Fentanyl and Remifentanil on Nausea, Vomiting, and Pain After Cesarean Section, Iranian Journal of Medical Sciences (2011)