Effect of Preemptive and Preventive Acetaminophen on Postoperative Pain Score: A Randomized, Double-Blind Trial of Patients Undergoing Lower Extremity Surgery Publisher Pubmed



Khalili G¹ ; Janghorbani M² ; Saryazdi H¹ ; Emaminejad A¹ Show Affiliations
Source: Journal of Clinical Anesthesia Published:2013

Abstract

Study Objective To compare postoperative pain scores and rescue analgesic use in patients who received acetaminophen preoperatively or during skin closure versus those who received a placebo. Design Randomized, double-blind clinical trial. Setting University-based, tertiary-care hospital. Patients 75 adult, ASA physical status 1 and 2 undergoing lower extremity orthopedic surgery. Interventions Patients were randomized to three groups. The control group received 100 mL of intravenous (IV) normal saline as a placebo. The preventive acetaminophen group received 100 mL of IV normal saline plus 15 mg/kg of acetaminophen prior to skin closure. The preemptive acetaminophen group received 15 mg/kg of IV acetaminophen combined with 100 mL of normal saline half an hour preoperatively. Measurements Pain was scored with the verbal rating scale and assessed 5 minutes before spinal anesthesia, and 6, 12, 18, and 24 hours after surgery. Total rescue meperidine consumption by each patient during the first 24 hours after surgery was also recorded. Main Results Pain scores were lower in both preemptive and preventive acetaminophen groups at 6 hours after surgery than in the placebo group (P < 0.001). There were no differences in pain scores after 6 hours between the preemptive and preventive groups. Total analgesic consumption 24 hours after surgery was lowest in the preemptive acetaminophen group (P < 0.01). Average time to initial analgesic requirement was slightly longer in the preemptive and preventive acetaminophen groups than the control group (P < 0.01). Conclusion In patients undergoing lower extremity surgery with spinal anesthesia, both preventive and preemptive acetaminophen may enhance analgesia and decrease postoperative analgesic consumption. © 2013 Elsevier Inc.