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Association Study Between Functional Polymorphisms of Mmp9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population



Sabbagh S1 ; Nadeali Z1, 2 ; Dehghani L3 ; Shaygannejad V1 ; Rezvani M4 ; Saboori M4 ; Ganji H1 ; Tahani S1 ; Dehghani F1 ; Hosseinzadeh S1 ; Marzbani E1 ; Shafiei P1
Authors
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Authors Affiliations
  1. 1. Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Medical Genetics Laboratory, Al-Zahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Public Health Published:2019

Abstract

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C-1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS pa-tients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of -90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA re-peats, further research is needed before proposing any definite conclusion. © 2019, Iranian Journal of Public Health. All rights reserved.
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