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Is Prehypertension a Risk Factors for Cardiovascular Diseases Among Iranian Women?



Aghababaei I1 ; Sadeghi M2 ; Talaei M1 ; Rabiei K1 ; Sarrafzadegan N1
Authors
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Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, PO BOX: 81465-1148, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

Background: Numerous studies have reported prehypertension (pre-HTN) as a risk factor for the cardiovascular diseases as hypertension (HTN). Aim: The present study aimed to evaluate the effects of pre-HTN on cardiovascular incidences among the females of Isfahan cohort study (ICS). Materials and Methods: Healthy female at baseline were followed for a median of 6.7 years. They were divided into 3 groups of normal blood pressure, pre-HTN (120/80 < BP < 139/89 mmHg) and HTN (BP > 140/90 mmHg) based on their baseline measurements. The endpoints were ischemic heart disease (IHD), stroke, CVD (combination of IHD and stroke) and mortality. Results: Normal BP, pre-HTN and HTN were observed in 1073 (33%), 1185 (36%), and 994 (31%) participants, respectively. One hundred and ninety-eight subjects developed CVDs and 110 died. In the HTN group, the hazard ratio [HRs (95% confidence interval)] adjusted for age and other risk factors were 3.44 (1.95-6.09) for IHD (P value < 0.001), 1.28 (0.59-2.77) for stroke (P value = 0.536) 4.89 (1.37-17.45) for CVD mortality (P value < 0.001) and 1.70 (0.98-2.96) for all cause mortality (P value = 0.060). Although, pre-HTN significantly increased the risk of IHD incidence in the crude model (HR 2.21, 95% CI 1.23-3.97) and after adjustments for age (HR 1.85, 95% CI 1.02-3.33), (P value < 0.001) the association did not remain statistically significant after including other risk factors in the model. Conclusion: Hypertension (HTN) to be a strong risk factor for CVD and IHD. However, in contrast to previous researches, pre-HTN was not found to be a risk factor for CVD, IHD or death independent to other risk factors in women.
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