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The Effect of Synbiotic Supplementation on Plasma Levels of Advanced Glycation End Products and Cardiovascular Risk Factors in Hemodialysis Patients: A Double-Blind Clinical Trial Publisher



Azamian Y1 ; Abdollahzad H2 ; Rezaeian S3 ; Rouhani MH4 ; Fatehi MH5
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Internal Medicine, Farabi Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Food Science and Nutrition Published:2024


Abstract

There is increasing evidence supporting the relationship between imbalance of gut microbiota and development of chronic kidney and cardiovascular diseases. This study aimed to investigate the effect of synbiotic supplementation on plasma levels of advanced glycation end products (AGEs) and cardiovascular risk factors in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled clinical trial, 36 HD patients were randomly allocated into two groups to receive two synbiotic supplements (n = 19) or placebo (n = 17) daily for 12 weeks. Levels of AGEs, fibrinogen, hemoglobin A1c (HbA1c), and other measures were assessed at the beginning and end of the study. The data were analyzed using independent t-tests, paired t-tests, and analysis of covariance (ANCOVA). At the end of the study, the plasma levels of AGEs increased significantly in both the synbiotic (p <.001) and control (p =.001) groups, but the difference between the groups was not significant (p =.272). Plasma levels of fibrinogen decreased specifically within the synbiotic group (p =.007), and a statistically significant disparity between the groups persisted at the study's conclusion (p =.016). The mean levels of blood urea nitrogen (BUN) decreased (p <.05) in both groups, but there was no difference between the two groups at the end of the study (p =.116). No significant differences were observed in other measured biomarkers. Synbiotic supplementation improved plasma fibrinogen and BUN levels in HD patients, but did not significantly improve AGEs and HbA1c. Further investigations are needed to investigate the effect of probiotics on AGEs in HD patients at different stages of kidney disease. © 2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.
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