Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effects of Pro-/Synbiotic Supplementation on Anthropometric and Metabolic Indices in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis Publisher Pubmed

Summary: Meta of 9 trials in 410 overweight kids: pro-/synbiotics don't change weight/waist/blood markers much. Synbiotics may slightly lower BMI scores—gut aids worth probing? #ChildObesity #GutHealth

Mohammadi H1 ; Ghavami A1 ; Hadi A2 ; Askari G3 ; Symonds M4 ; Miraghajani M4, 5
Authors

Source: Complementary Therapies in Medicine Published:2019


Abstract

Background & aims: Existing evidence on the possible effects of pro-/synbiotics on overweight or obese children and adolescents has not been fully established. Therefore, the present review was undertaken to evaluate the overall effects of pro-/synbiotics supplementation on anthropometric indices and metabolic indices in overweight or obese children and adolescents. Methods: A systematic computerized literature search of PubMed, Scopus, ISI Web of science and Google Scholar databases was conducted up to November 2018. All RCTs using pro-/synbiotics supplements in overweight or obese children and adolescents included in this systematic review and meta-analysis. Results: Overall 9 randomized trials including 410 subjects were identified for the present meta-analysis. Pooled analysis did not illustrate any significant changes in BMI z-score, waist circumference, weight, body fat, fasting blood sugar and lipid profiles (triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) after supplementation with pro-/synbiotics for 4–16 weeks. However, subgroup analysis by intervention type revealed a significant reduction of BMI z-score in synbiotic subgroups. Conclusion: Based on our findings, modulation of gut microbiota composition through pro-/ synbiotic supplements did not have favorable effects to manage overweight or obese children and adolescents. Further large-scale studies are warranted to confirm present findings. © 2019 Elsevier Ltd
Related Docs
View other Related Docs
1. Efficacy of Synbiotic Supplementation in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Critical Reviews in Food Science and Nutrition (2020)
2. Effects of Synbiotic Supplementation on Anthropometric Indices and Body Composition in Overweight or Obese Children and Adolescents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, World Journal of Pediatrics (2023)
3. The Effects of Synbiotic Supplementation on Some Cardio-Metabolic Risk Factors in Overweight and Obese Children: A Randomized Triple-Masked Controlled Trial, International Journal of Food Sciences and Nutrition (2013)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (4)
Mahin Hashemipour (3)
Effects of Pro-/Synbiotic Supplementation on Anthropometric and Metabolic Indices in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis
Other Related Docs
4. Effects of Synbiotics Supplementation on Anthropometric and Lipid Profile Parameters: Finding From an Umbrella Meta-Analysis, Frontiers in Nutrition (2023)
5. Effects of Probiotics Fermented Milk Products on Obesity Measure Among Adults: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Functional Foods (2021)
6. A Randomized Triple-Masked Controlled Trial on the Effects of Synbiotics on Inflammation Markers in Overweight Children, Jornal de Pediatria (2014)
7. Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition (2021)
8. The Effect of Synbiotic Supplementation on Anthropometric Indices, Appetite, and Constipation in People With Hypothyroidism: A Randomized, Double-Blind, Placebo-Controlled Trial, Phytotherapy Research (2020)
9. The Effect of Probiotics on Lipid Profile & Anthropometric Indices in Diabetic Nephropathy; a Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2021)
10. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
11. Efficacy of Synbiotic Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials: Synbiotic Supplementation and Nafld, Critical Reviews in Food Science and Nutrition (2019)
12. Probiotic Supplementation for Management of Cardiovascular Risk Factors in Adults With Type Ii Diabetes: A Systematic Review and Meta-Analysis, Clinical Nutrition (2018)
13. Effect of Probiotics on Oxidative Stress and Inflammatory Status in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2021)
14. Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents, Journal of Pediatric Gastroenterology and Nutrition (2017)
15. The Effect of Magnesium Supplementation on Anthropometric Indices: A Systematic Review and Dose-Response Meta-Analysis of Clinical Trials, British Journal of Nutrition (2021)
16. Can Probiotics Supplementation Improve Glycemic and Renal Status in Diabetic Nephropathy? a Systematic Review and Meta-Analysis of Clinical Trials, Endocrine, Metabolic and Immune Disorders - Drug Targets (2022)
17. Probiotic Soy Beverages: A Functional Beverage on Lipid Profile, Oxidative Stress and Kidney Function: A Systematic Review of Randomized Controlled Trials, Nutrition and Food Science (2025)
18. Systematic Review With Meta-Analysis: Effects of Probiotic Supplementation on Symptoms in Functional Dyspepsia, Journal of Functional Foods (2020)
19. The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Lipids in Health and Disease (2020)
20. Effects of Probiotics and Synbiotic on Lipid Profiles in Adults at Risk of Type 2 Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Functional Foods in Health and Disease (2019)