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Can Probiotics Supplementation Improve Glycemic and Renal Status in Diabetic Nephropathy? a Systematic Review and Meta-Analysis of Clinical Trials Publisher Pubmed



Tarrahi MJ1 ; Namjoo I2 ; Borzooisfahani M3 ; Ebdali H4 ; Moravejolahkami AR5
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sci-ences, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Food Science and Technology, School of Nutrition and Food Sci-ence, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Endocrine, Metabolic and Immune Disorders - Drug Targets Published:2022


Abstract

Background & Aim: This meta-analysis was performed to quantify the effects of probi-otics on renal and glycemic biomarkers among patients with Diabetic Nephropathy (DN). Methods: Electronic databases were searched on May 10, 2020. All trials that investigated the effect of probiotics on serum glycemic markers (Fasting Plasma Glucose [FPG], Hemoglobin A1C, Insulin, Homeostatic Model Assessment-Insulin Resistance [HOMA-IR], and Quantitative Insulin Sensitivity Check Index [QUICKI]), and renal status markers (Creatinine [Cr], Blood Urea Nitro-gen [BUN], and Glomerular Filtration Rate [GFR]) were included. Results: Seven trials that included 340 patients were identified for analysis. The results indicated that probiotics significantly reduced FPG (WMD=-19.08 mg/dl; 95% CI=-32.16,-5.99; P=0.004), HOMA-IR (WMD=-1.88; 95% CI=-3.63,-0.12; P=0.036), and Cr (WMD=-0.18 mg/dl; 95% CI=-0.26,-0.09; P<0.001) levels in DN patients; however, there was no statistically significant change in Hemoglobin A1C, Insulin, QUICKI, BUN, and GFR. Conclusion: This meta-analysis supports the potential use of probiotics in the improvement of some glycemic and renal biomarkers in patients with DN. © 2022 Bentham Science Publishers.
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