Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Garlic (Allium Sativum) Supplementation on the Lipid Parameters and Blood Pressure Levels in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial Publisher Pubmed



Zadhoush R1 ; Alavinaeini A1 ; Feizi A2 ; Naghshineh E3 ; Ghazvini MR4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran

Source: Phytotherapy Research Published:2021


Abstract

Polycystic ovary syndrome (PCOS) is the most prevalent female endocrine-related disorder in reproductive ages. The aim of the study was to investigate the effect of garlic on the lipid parameters and blood pressure levels in women with PCOS. The present study was a randomized, double-blinded control trial, conducted on 80 PCOS patients. Participants were taught to intake either a total 800 mg/day garlic supplement or an identical placebo (starch) after lunch for 8 weeks. Physical activity, diet intake, anthropometric measures, and blood pressure were evaluated at baseline and end of the study. The blood sample was also taken to assess the change in outcomes of interest at the pre- and post-intervention. Garlic supplementation significantly reduced serum total cholesterol (change mean difference: −8.05, 95% CI: −15.47, −0.62) and LDL-C (change mean difference: −7.67, 95%CI: −14.64, −0.70) levels in comparison to the control group. In addition, a trend to a significant decrease was found in serum triglyceride levels and Systolic blood pressure; however, no significant difference was observed between two groups in HDL-C and diastolic blood pressure levels. The present study suggested that garlic supplementation might be effective on lipid markers improvement. Further studies are needed to confirm our findings. © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. The Effect of Garlic (Allium Sativum) on Polycystic Ovary Syndrome Related Hormones and Glycemic Parameters: A Randomized, Double-Blinded Clinical Trial, International Journal of Preventive Medicine (2023)
2. The Therapeutic Impact of Garlic (Allium Sativum) on Oxidative Stress Markers Among Polycystic Ovary Syndrome Patients: A Randomized, Double-Blinded Clinical Trial, International Journal of Preventive Medicine (2023)
3. Association Between Major Dietary Patterns and Polycystic Ovary Syndrome: Evidence From a Case-Control Study, Applied Physiology, Nutrition and Metabolism (2019)
4. Comparison of the Impact of Intermittent Fasting Diet Alone or in Conjunction With Probiotic Supplementation Versus Calorie-Restricted Diet on Inflammatory, Oxidative Stress, and Antioxidant Capacity Biomarkers in Women With Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Trial, Journal of Research in Medical Sciences (2025)
5. The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Lipids in Health and Disease (2020)
6. Effects of Dash Diet on Lipid Profiles and Biomarkers of Oxidative Stress in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial, Nutrition (2014)
7. Association Between the Food Security Status and Dietary Patterns With Polycystic Ovary Syndrome (Pcos) in Overweight and Obese Iranian Women: A Case-Control Study, Journal of Ovarian Research (2021)
8. The Relationship Between Intake of Dairy Products and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics in 2013, International Journal of Preventive Medicine (2014)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (16)
Roya Kelishadi (12)
Other Related Docs
9. The Association Between Anthropometric Parameters and Cardiovascular Risk Indicators in Women With Polycystic Ovarian Syndrome, ARYA Atherosclerosis (2020)
10. The Effect of Concentrated Pomegranate Juice Consumption on Risk Factors of Cardiovascular Diseases in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2021)
11. Omega-3 Supplementation Effects on Polycystic Ovary Syndrome Symptoms and Metabolic Syndrome, Journal of Research in Medical Sciences (2017)
12. The Effects of Canola and Olive Oils Consumption Compared to Sunflower Oil, on Lipid Profile and Hepatic Steatosis in Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial, Lipids in Health and Disease (2021)
13. The Effects of Garlic Supplementation on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
14. Systematic Review and Meta-Analysis of Randomised, Controlled Trials on the Effects of Garlic Supplementation on Serum Adiponectin and Leptin Levels, International Journal of Clinical Practice (2021)
15. The Effects of Curcumin Supplementation on Glycemic Status, Lipid Profile and Hs-Crp Levels in Overweight/Obese Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Complementary Therapies in Medicine (2019)
16. Effect of Garlic and Lemon Juice Mixture on Fasting Blood Sugar, Diastolic and Systolic Blood Pressure and Body Mass Index in People With Hyperlipidemia, Journal of Isfahan Medical School (2015)
17. Calcium Plus Vitamin D Supplementation Affects Glucose Metabolism and Lipid Concentrations in Overweight and Obese Vitamin D Deficient Women With Polycystic Ovary Syndrome, Clinical Nutrition (2015)
18. A Meta-Analysis of Effects of Vitamin E Supplementation Alone and in Combination With Omega-3 or Magnesium on Polycystic Ovary Syndrome, Scientific Reports (2022)
19. Prevalence of Polycystic Ovary Syndrome in Reproductive-Aged Women With Type 2 Diabetes, Gynecological Endocrinology (2008)
20. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
21. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
22. The Effect of Fresh Garlic on the Lipid Profile and Atherosclerosis Development in Male Rats Fed With a High Ghee Diet, International Journal of Pharmacy and Pharmaceutical Sciences (2015)
23. The Association Between Dietary Antioxidants, Oxidative Stress Markers, Abdominal Obesity and Poly-Cystic Ovary Syndrome: A Case Control Study, Journal of Obstetrics and Gynaecology (2020)
24. Effect of Garlic and Lemon Juice Mixture on Lipid Profile and Some Cardiovascular Risk Factors in People 30-60 Years Old With Moderate Hyperlipidaemia: A Randomized Clinical Trial, International Journal of Preventive Medicine (2016)
25. The Effect of Concentrated Pomegranate Juice on Biomarkers of Inflammation, Oxidative Stress, and Sex Hormones in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2023)
26. Calcium Plus Vitamin D Supplementation Influences Biomarkers of Inflammation and Oxidative Stress in Overweight and Vitamin D-Deficient Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Clinical Endocrinology (2015)
27. Comparison of the Effects of Metformin, Flutamide Plus Oral Contraceptives, and Simvastatin on the Metabolic Consequences of Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2016)
28. The Effects of Chromium Supplementation on Endocrine Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Biological Trace Element Research (2016)
29. Effect of Probiotics and Synbiotics on Selected Anthropometric and Biochemical Measures in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, European Journal of Clinical Nutrition (2020)
30. Effect of Soy Phytoestrogen on Metabolic and Hormonal Disturbance of Women With Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2011)
31. Cardiometabolic Risk Factors in Polycystic Ovary Syndrome, Pakistan Journal of Medical Sciences (2012)
32. Effect of Garlic Powder Supplementation on Blood Pressure and Hs-C-Reactive Protein Among Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Food Science and Nutrition (2021)
33. Metabolic Response to Folate Supplementation in Overweight Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Molecular Nutrition and Food Research (2014)
34. Comparison of the Metabolic Parameters and Androgen Level of Umbilical Cord Blood in Newborns of Mothers With Polycystic Ovary Syndrome and Controls, Journal of Research in Medical Sciences (2012)
35. Effects of Eicosapentaenoic Acid and Vitamin C on Glycemic Indices, Blood Pressure, and Serum Lipids in Type 2 Diabetic Iranian Males, Journal of Research in Medical Sciences (2011)
36. The Effect of Brassica Vegetables on Blood Glucose Levels and Lipid Profiles in Adults. a Systematic Review and Meta-Analysis, Phytotherapy Research (2022)
37. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
38. The Effect of Garlic Intake on Glycemic Control in Humans: A Systematic Review and Meta-Analysis, Progress in Nutrition (2017)
39. Health System-Related Needs for Healthy Nutritional Behaviors in Adolescent Girls With Polycystic Ovary Syndrome (Pcos): A Qualitative Study in Iran, BMC Health Services Research (2022)
40. Effects of Cardamom Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Phytotherapy Research (2020)
41. An Unhealthy Plant-Based Diet Increases Risk of Hypertension But Not Framingham Risk Score in Adults, Current Developments in Nutrition (2023)
42. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Evaluating the Garlic Supplement Effects on Some Serum Biomarkers of Oxidative Stress, and Quality of Life in Women With Rheumatoid Arthritis, International Journal of Clinical Practice (2020)
43. Effects of the Dietary Approaches to Stop Hypertension (Dash) Eating Plan on the Metabolic Side Effects of Corticosteroid Medications, Journal of the American College of Nutrition (2016)
44. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
45. Association of Dietary Acid Load With Cardiovascular Risk Factors and the Prevalence of Metabolic Syndrome in Iranian Women: A Cross-Sectional Study, Nutrition (2019)
46. Effects of Therapeutic Lifestyle Change Diets on Blood Lipids, Lipoproteins, Glycemic Parameters, and Blood Pressure: A Systematic Review and Meta-Analysis of Clinical Trials, Nutrition Reviews (2024)
47. Age-, Sex-, and Puberty-Associated Reference Intervals for Lipid Profile in Iranian Children and Adolescents, International Journal of Endocrinology (2023)
48. Dietary Fatty Acid Intakes and the Outcomes of Assisted Reproductive Technique in Infertile Women, Journal of Reproduction and Infertility (2021)
49. Healthy Eating Index and Risk of Diminished Ovarian Reserve: A Case–Control Study, Scientific Reports (2024)
50. The Effect of Low Glycemic Index Diet on Body Weight Status and Blood Pressure in Overweight Adolescent Girls: A Randomized Clinical Trial, Nutrition Research and Practice (2013)