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The Effect of Fresh Garlic on the Lipid Profile and Atherosclerosis Development in Male Rats Fed With a High Ghee Diet



Salehi I1 ; Vahidinia A2 ; Bakhtiari A3 ; Mohammadi P4 ; Sukumaran A5 ; Hosseinizijoud SM6
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Paramedicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Nutrition and Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Division of Periodontics, College of Dentistry, King Saud University, Saudi Arabia
  6. 6. Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: International Journal of Pharmacy and Pharmaceutical Sciences Published:2015

Abstract

Objective: Garlic has a protective effect against hyperlipidemia and ghee in diet is considered as a risk factor for hyperlipidemia. We examined the effects of fresh garlic administration on body weight, lipid profiles and plaque formation in the male rats fed with a high ghee diet. Methods: Twenty-four male Wistar rats were randomly divided into 3 groups of 8. The control group consumed an ordinary diet, Group 2 received the 31% ghee pellets (high ghee diet) and group 3 received the 8% garlic+31% ghee pellets. After 9 mo, serum levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and atherosclerotic index (AI) were examined. Changes in body weight, daily food intake and plaque formation also were assayed in this survey. Results: The high ghee diet induced the significant increase (P<0.05) in serum concentrations of TC, TG and HDL-C, and a decrease in LDL-C concentration (group 2). While fresh garlic increased TG (P<0.05) and HDL-C levels and declined TC and LDL-C in treated rats (group 3). Meanwhile, ghee and garlic showed a favorable effect in reducing AI (P<0.05). No histopathological changes were observed in the Aorta of the rats. Conclusion: Evidence obtained from this study indicates that ghee and fresh garlic has potential effects in the prevention and control of hyperlipidemia complications and are beneficial when taken as a dietary supplement. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All rights reserved.
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