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The Association Between Anthropometric Parameters and Cardiovascular Risk Indicators in Women With Polycystic Ovarian Syndrome Publisher



Mirdamadi A1 ; Riahinejad S2 ; Varnaseri S3
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, School of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
  2. 2. Department of Gynecology, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
  3. 3. Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2020


Abstract

BACKGROUND: In patients with polycystic ovarian syndrome (PCOS), this is now hypothesized that whether increased risk for cardiovascular disorders is related more to obesity than PCOS per se. This study aimed to compare cardiovascular risk factors between the lean and obese women with PCOS. METHODS: This case-control study was conducted on 86 (43 obese and 43 lean) women with PCOS. The presence of overweight and obesity was defined based on the body mass index (BMI) (> 25 kg/m2). The study objectives were first to compare mean levels of cardiovascular laboratory parameters between lean and obese patients with PCOS and then to assess the relationship between obesity indices and these laboratory parameters. RESULTS: Compared to the lean group, the obese group had significantly higher mean fasting blood sugar (FBS) (89.40 ± 10.73 versus 84.09 ± 7.87 mg/dl, P = 0.011), higher mean serum triglyceride (TG) (119.09 ± 60.66 versus 96.86 ± 27.23 mg/dl, P = 0.032), higher mean total cholesterol (147.70 ± 57.38 versus 126.79 ± 35.95 mg/dl, P = 0.045), and also higher mean lowdensity lipoprotein (LDL) (92.30 ± 13.53 versus 83.77 ± 17.61 mg/dl, P = 0.014). Using the Pearson’s correlation test, positive correlations were found between BMI and waist circumference (WC) indices and study parameters including FBS, serum TG, serum total cholesterol, serum LDL, and also blood pressure (BP). CONCLUSION: Because of higher concentrations of FBS and lipid profiles in obese patients with PCOS and considering obesity as a more important risk factor for coronary artery disease (CAD) than PCOS, it is recommended to assess and monitor cardiovascular risk factors in these population to reduce the risk for cardiovascular disorders and metabolic syndrome. Also, by reducing body weight and normalizing BMI value, the cardiovascular and metabolic risk factors can be modified and prevented. © 2020, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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