Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Dietary Magnesium Intake With Serum Brain-Derived Neurotrophic Factor (Bdnf) and Adropin Levels and Metabolic Health Status in Iranian Adults Publisher Pubmed



Rahimi M1, 2 ; Tirani SA1, 2 ; Shahdadian F1, 3 ; Hajhashemy Z1, 2 ; Rouhani P4 ; Mohammadi S5 ; Mokhtari E1, 2 ; Saneei P2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Biological Trace Element Research Published:2024


Abstract

Given the sparse conclusive findings regarding the association of magnesium intake with metabolic health status and limited evidence relating magnesium intake to metabolic biomarkers, our objective was to evaluate the association of metabolic health status, adropin, and brain-derived neurotrophic factor (BDNF) in relation to dietary magnesium intake. In this cross-sectional study, 527 male and female adults were investigated in Isfahan City. The data regarding usual dietary intakes were gathered using a valid and reliable 168-item food frequency questionnaire. Biochemical variables, anthropometric indices, and blood pressure were assessed following standard methods. The criteria suggested by Wildman et al. were used to classify participants as metabolically unhealthy (MU) and metabolically healthy (MH). Moderate magnesium intake was associated with 71% reduced odds of MU (OR T2 vs. T1 = 0.29; 95% CI: 0.12–0.70). In the stratified analysis, the inverse association between moderate intake of magnesium and MU was seen only in overweight/obese subjects but not in normal-weight ones. A significant difference was found in serum levels of adropin between the first and second tertile of dietary magnesium intake among overweight/obese subjects (62.74 ± 4.99 vs. 50.13 ± 2.54, P = 0.03). After adjustment for potential covariates, this association became attenuated (59.06 ± 3.47 vs. 50.02 ± 3.64, P = 0.20). No statistically significant link was obtained between dietary intake of magnesium and circulating BDNF levels. Moderate dietary intake of magnesium may exert beneficial effects on metabolic health and serum levels of adropin, especially in obese/overweight individuals. Further prospective studies will be required to approve our findings. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. Dietary Intake of Methyl Donor Nutrients in Relation to Metabolic Health Status, Serum Levels of Brain-Derived Neurotrophic Factor and Adropin, Clinical Nutrition (2024)
2. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
3. Association Between Mediterranean Diet and Metabolic Health Status Among Adults Was Not Mediated Through Serum Adropin Levels, BMC Public Health (2025)
4. Ultra-Processed Foods Intake in Relation to Metabolic Health Status, Serum Brain-Derived Neurotrophic Factor and Adropin Levels in Adults, Nutrition Journal (2024)
5. Legumes and Nuts Intake in Relation to Metabolic Health Status, Serum Brain Derived Neurotrophic Factor and Adropin Levels in Adults, Scientific Reports (2023)
6. Adherence to Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay Diet in Relation to Serum Brain-Derived Neurotrophic Factor Concentrations and Metabolic Health Status in Adults, Current Developments in Nutrition (2024)
7. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
8. Nutrient Patterns in Relation to Metabolic Health Status and Serum Levels of Brain-Derived Neurotrophic Factor (Bdnf) and Adropin in Adults, Scientific Reports (2024)
Experts (# of related papers)
View all Related Experts
Parvane Saneei (30)
Noushin Mohammadifard (27)
Other Related Docs
9. Magnesium Status and the Metabolic Syndrome: A Systematic Review and Meta-Analysis, Nutrition (2016)
10. Association of Plant-Based Diets With Adropin, Atherogenic Index of Plasma, and Metabolic Syndrome and Its Components: A Cross-Sectional Study on Adults, Frontiers in Nutrition (2023)
11. Diet in Relation to Metabolic, Sleep and Psychological Health Status (Dimets): Protocol for a Cross-Sectional Study, BMJ Open (2023)
12. Effect of Oral Magnesium Supplement on Cardiometabolic Markers in People With Prediabetes: A Double Blind Randomized Controlled Clinical Trial, Scientific Reports (2022)
13. Association Between Methyl Donor Nutrients And Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2022)
14. Dietary Magnesium Intake, Bone Mineral Density and Risk of Fracture: A Systematic Review and Meta-Analysis, Osteoporosis International (2016)
15. The Effects of Magnesium Supplementation on Lipid Profile Among Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Biological Trace Element Research (2021)
16. Nutrient Intake and Unhealthy Dietary Pattern of Iranian Women: A Cross Sectional Study, Progress in Nutrition (2018)
17. Relationship Between Dietary Patterns and Mild Cognitive Impairment (Mci) in Elderly Women, Progress in Nutrition (2019)
18. Associations Between Serum Magnesium Concentrations and Polycystic Ovary Syndrome Status: A Systematic Review and Meta-Analysis, Biological Trace Element Research (2021)
19. Association Between Plant-Based Diets and Metabolic Syndrome in Obese Adults From Iran: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
20. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
21. The Relationship Between the Mediterranean-Dash Intervention for Neurodegenerative Delay (Mind) Diet and Metabolic Health Status in Adolescents With Overweight and Obesity: Results From a Cross-Sectional Study in Iran, British Journal of Nutrition (2024)
22. The Association Between Lipid Profile, Oxidized Ldl and the Components of Metabolic Syndrome With Serum Mineral Status and Kidney Function in Individuals With Obesity, BMC Research Notes (2023)
23. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
24. Prevalence of Metabolically Healthy Obesity and Healthy Overweight and the Associated Factors in Southern Iran: A Population-Based Cross-Sectional Study, Health Science Reports (2024)
25. Oral Magnesium Supplementation Improved Lipid Profile But Increased Insulin Resistance in Patients With Diabetic Nephropathy: A Double-Blind Randomized Controlled Clinical Trial, Biological Trace Element Research (2020)
26. Magnesium Supplementation Affects Metabolic Status and Pregnancy Outcomes in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, American Journal of Clinical Nutrition (2015)
27. The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance, Advanced Biomedical Research (2022)
28. Pivotal Role of Mediterranean Dietary Regimen in the Increase of Serum Magnesium Concentration in Patients With Coronary Artery Disease, Journal of Nutrition and Metabolism (2013)
29. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
30. Oral Herbal Supplement Containing Magnesium Sulfate Improve Metabolic Control and Insulin Resistance in Non-Diabetic Overweight Patients: A Randomized Double Blind Clinical Trial, Medical Journal of the Islamic Republic of Iran (2019)
31. Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2021)
32. Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention, Scientific World Journal (2023)
33. The Relationship Between Dietary Patterns and Metabolic Phenotypes: A Cross-Sectional Study in a Representative Sample of Iranian Industrial Employees, Metabolic Syndrome and Related Disorders (2024)
34. Dietary Intake of Minerals in the Patients With Stroke, Journal of Research in Medical Sciences (2013)
35. Is Urinary Sodium Excretion Related to Anthropometric Indicators of Adiposity in Adults?, Journal of Research in Medical Sciences (2020)
36. Adherence to Lifelines Diet Score and Risk Factors of Metabolic Syndrome Among Overweight and Obese Adults: A Cross-Sectional Study, Frontiers in Nutrition (2022)
37. The Association Between Dietary Glycemic Index, Glycemic Load and Diet Quality Indices in Iranian Adults: Results From Isfahan Healthy Heart Program, International Journal of Food Sciences and Nutrition (2016)
38. The Association Between Carbohydrate Intake and Metabolic Syndrome, Journal of Isfahan Medical School (2011)
39. The Epigenetic Overlap Between Obesity and Mood Disorders: A Systematic Review, International Journal of Molecular Sciences (2020)
40. Egg Consumption in Relation to Glioma: A Case–Control Study, Nutrition and Cancer (2019)
41. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
42. Adherence to Low Carbohydrate Diet in Relation to Glioma: A Case-Control Study, Clinical Nutrition (2019)
43. Total Dietary Fiber Intake Is Inversely Associated With Metabolically Unhealthy Status in Adolescents With Excess Weight, Nutrition Research (2024)
44. The Association Between Autism Spectrum Disorders and Dietary Intake of Carbohydrates in School-Aged Children in Iran: A Case–Control Study, Neuropsychopharmacology Reports (2025)
45. Does Water Hardness Have Preventive Effect on Cardiovascular Disease?, International Journal of Preventive Medicine (2014)
46. A Case-Control Study on Dietary Acid Load in Relation to Glioma, Nutrition and Cancer (2022)
47. Effect of Vitamin D and Magnesium Supplementation on Behavior Problems in Children With Attention-Deficit Hyperactivity Disorder, International Journal of Preventive Medicine (2020)
48. Effect of Magnesium Sulfate Administration to Improve Insulin Resistance in Type 2 Diabetes Animal Model: Using the Hyperinsulinemic-Euglycemic Clamp Technique, Fundamental and Clinical Pharmacology (2018)
49. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
50. Association of Glycaemic Index and Glycaemic Load With Metabolic Syndrome in an Iranian Adult Population: Isfahan Healthy Heart Program, Nutrition and Dietetics (2017)